{"id":"W3093010777","doi":"10.1016/j.ymthe.2020.10.012","title":"Fetal and Maternal Safety Considerations for In Utero Therapy Clinical Trials: iFeTiS Consensus Statement","year":2020,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Horizon 2020; Medical Research Council; National Institutes of Health; German-Israeli Foundation for Scientific Research and Development; UCLH Biomedical Research Centre; Horizon 2020 Framework Programme; Bundesministerium für Bildung und Forschung; National Centre for the Replacement Refinement and Reduction of Animals in Research; California Institute for Regenerative Medicine; Stichting Dioraphte; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Chang Gung Medical Foundation; National Institute for Health and Care Research; National Heart, Lung, and Blood Institute; Vetenskapsrådet; National Foundation for Ectodermal Dysplasias; Ministry of Health -Singapore; European Commission; University College London; Chang Gung Memorial Hospital; National Medical Research Council; Edimer Pharmaceuticals; Deutsche Forschungsgemeinschaft","keywords":"In utero; Fetus; Medicine; Genetic enhancement; Transplantation; Cell therapy; Gestation; Intensive care medicine; Pregnancy; Stem cell; Biology; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.274704,0.002189382,0.006117467,0.005511555,0.005056593,0.01645433,0.01498673,0.05408962,0.01215632],"category_scores_gemma":[0.2966893,0.002544925,0.01263096,0.005843777,0.007838436,0.01068987,0.01011046,0.03809533,0.01301625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01003079,"about_ca_system_score_gemma":0.05758497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004138221,"about_ca_topic_score_gemma":0.004914503,"domain_scores_codex":[0.8006462,0.103846,0.0481812,0.006941548,0.03180841,0.008576598],"domain_scores_gemma":[0.5470411,0.2488273,0.03871212,0.01699454,0.1202112,0.0282137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000433421,0.000171443,0.0007603326,0.01161023,0.0004242542,0.0005290196,0.001000779,0.0008835078,0.0008778889,0.02189362,0.7521551,0.2092604],"study_design_scores_gemma":[0.0002440264,0.0001393854,0.0009547092,0.03381123,0.0003351247,0.0006165153,0.0003513721,0.0004610642,0.0004172309,0.01650221,0.9460654,0.0001016304],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.0008867082,0.09465814,0.01688365,0.8059693,0.03885258,0.003861267,0.002191536,0.0006961316,0.03600072],"genre_scores_gemma":[0.01247951,0.08200965,0.107412,0.7264683,0.03325714,0.01349813,0.004564169,0.0006976728,0.01961337],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.274704,"threshold_uncertainty_score":0.8944191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2931027557703753,"score_gpt":0.4917923277354491,"score_spread":0.1986895719650738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}