{"id":"W3093022522","doi":"10.1186/s12916-020-01749-w","title":"Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments","year":2020,"lang":"en","type":"review","venue":"BMC Medicine","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Health and Medical Research Council","keywords":"Endothelial dysfunction; Oxidative stress; NADPH oxidase; Cell biology; Medicine; Enos; Reactive oxygen species; Apocynin; PI3K/AKT/mTOR pathway; Nitric oxide; Internal medicine; Nitric oxide synthase; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007787859,0.0004664122,0.001227039,0.0002738129,0.00006741115,0.00002211374,0.0002283973,0.0001560932,0.0001141465],"category_scores_gemma":[0.001596904,0.0003124751,0.0001155317,0.0006487022,0.000305983,0.00007789428,0.00008779108,0.0003288606,0.00007210192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000469711,"about_ca_system_score_gemma":0.0001265591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003183193,"about_ca_topic_score_gemma":0.00007579957,"domain_scores_codex":[0.9976282,0.0004110968,0.0004979903,0.0008454522,0.0003131385,0.0003041667],"domain_scores_gemma":[0.9985014,0.0007871932,0.000273515,0.0002742329,0.000008459016,0.0001552589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000387478,0.00009240006,0.0001069845,0.003208387,0.00001400392,0.0001237766,0.0001461618,1.308921e-7,0.00006050312,0.0001351588,0.0003357204,0.995738],"study_design_scores_gemma":[0.002471311,0.0005206253,0.0002646119,0.004801305,0.0002193232,0.00007838341,0.00006113507,0.00001359768,0.0000218374,0.0001006129,0.991137,0.0003102859],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000258744,0.9967061,0.00001449024,0.0002038134,0.0005426581,0.001219175,0.00003935485,0.0001098082,0.0009058626],"genre_scores_gemma":[0.0003991258,0.9984438,0.00001707608,0.0002818955,0.0002794296,0.0001343721,0.00003511583,0.0000600051,0.0003491122],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9954277,"threshold_uncertainty_score":0.9999327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0707644695962379,"score_gpt":0.3365590236102134,"score_spread":0.2657945540139756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}