{"id":"W3093050747","doi":"10.1530/eje-20-0866","title":"MECHANISMS IN ENDOCRINOLOGY: Pioneer transcription factors in pituitary development and tumorigenesis","year":2020,"lang":"en","type":"review","venue":"European Journal of Endocrinology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Epigenome; Biology; Enhancer; Transcription factor; Cell fate determination; Pioneer factor; Chromatin; Heterochromatin; Context (archaeology); Genetics; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002618516,0.0004073072,0.001117068,0.0004052039,0.00003444813,0.00001637533,0.0004270922,0.0001166075,0.000009523473],"category_scores_gemma":[0.00005997715,0.0003578817,0.0002186109,0.0001323548,0.00006518803,0.000005966257,0.0001877327,0.0005375435,0.00000843739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008079841,"about_ca_system_score_gemma":0.000236437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003443985,"about_ca_topic_score_gemma":0.00003343961,"domain_scores_codex":[0.9972333,0.0006061596,0.001217823,0.0003972896,0.000105257,0.0004402214],"domain_scores_gemma":[0.9991153,0.0000262899,0.0005119268,0.0001899253,0.00004170635,0.0001148001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008580496,0.0002190782,0.0003883485,0.002042241,0.0004917752,0.005232452,0.0006518957,0.00003644505,0.007536528,0.0005921667,0.0001112987,0.982612],"study_design_scores_gemma":[0.0009830353,0.0005880342,0.001929713,0.0007590488,0.0001316947,0.002027082,0.0002054236,0.000002680119,0.0006237263,0.00004883982,0.9922399,0.0004608017],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07406896,0.9244407,0.0005440362,0.00005180124,0.0004478772,0.0002329618,0.00001443977,0.000005584839,0.0001936628],"genre_scores_gemma":[0.03770991,0.959806,0.002152109,0.00004574485,0.0001025299,0.000005411615,0.00006981006,0.00007273436,0.00003570276],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9921286,"threshold_uncertainty_score":0.9998873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02554316611394779,"score_gpt":0.2500244857420181,"score_spread":0.2244813196280703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}