{"id":"W3093091675","doi":"10.1016/j.biologicals.2020.09.003","title":"Replacing the in vivo toxin challenge test with an in vitro assay for assessment of potency for diphtheria toxoid containing vaccines","year":2020,"lang":"en","type":"article","venue":"Biologicals","topic":"Diphtheria, Corynebacterium, and Tetanus","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Diphtheria toxin; Potency; Diphtheria; Toxoid; In vivo; Immunization; In vitro toxicology; Medicine; Virology; In vitro; Antibody; Toxin; Vaccination; Microbiology; Chemistry; Biology; Immunology; Biotechnology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002053797,0.002564936,0.001733897,0.001174502,0.0006556885,0.001392846,0.001161394,0.001958428,0.002831996],"category_scores_gemma":[0.003548359,0.000871739,0.001136797,0.0009968042,0.0013554,0.001221575,0.001233415,0.005146162,0.002503295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008563921,"about_ca_system_score_gemma":0.001442534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002837701,"about_ca_topic_score_gemma":0.003445447,"domain_scores_codex":[0.9953882,0.00205555,0.000349547,0.0005382076,0.001241707,0.000426867],"domain_scores_gemma":[0.9939165,0.002677683,0.0005240306,0.001272724,0.001183071,0.0004260568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00023711,0.0004149306,0.0005014653,0.0001079911,0.00001492164,0.00002407098,0.00008291347,0.0001962974,0.9958408,0.0002242707,0.0001300601,0.002225086],"study_design_scores_gemma":[0.00001739053,0.002642087,0.001142796,0.00001327993,0.00002756773,0.0001004908,0.00003308531,0.0007033785,0.9943328,0.00007939185,0.0008928194,0.0000148964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6803087,0.003180336,0.2859269,0.0007810729,0.001955101,0.003499465,0.003658632,0.00248234,0.01820744],"genre_scores_gemma":[0.841022,0.002741955,0.1202918,0.0008388619,0.0002931362,0.002625778,0.005512992,0.0006306571,0.02604278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002837701,"threshold_uncertainty_score":0.01086164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03901331657394204,"score_gpt":0.3004869090676396,"score_spread":0.2614735924936976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}