{"id":"W3093094957","doi":"10.1038/s41588-020-00731-9","title":"Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor","year":2020,"lang":"en","type":"article","venue":"Nature Genetics","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":269,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Kent State University; Deutsche Forschungsgemeinschaft; National Institute on Aging; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Gene isoform; Interferon; Virology; TMPRSS2; Coronavirus; Interferon type I; Interferon-stimulated gene; Virus; Receptor; Gene; Coronavirus disease 2019 (COVID-19); Genetics; Innate immune system; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000206606,0.0003707127,0.0002263975,0.0001517639,0.000222483,0.0004638293,0.000180164,0.0002701792,0.002410718],"category_scores_gemma":[0.0001780116,0.0002030739,0.0005516962,0.00007023906,0.0002708146,0.000264999,0.0001607831,0.0007683848,0.0007752008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003797549,"about_ca_system_score_gemma":0.0002594616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003552504,"about_ca_topic_score_gemma":0.0006358624,"domain_scores_codex":[0.9998425,0.00002211185,0.00001563559,0.00003170704,0.00003636672,0.00005168054],"domain_scores_gemma":[0.9997498,0.00005125581,0.00005618788,0.00004180506,0.00002592875,0.00007495008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001729204,0.00001599626,0.0001415317,0.00000767247,0.000004880073,0.00009440168,0.000005767047,0.00002444735,0.9991443,0.0001101172,0.0000361316,0.0002417457],"study_design_scores_gemma":[0.000108703,0.000475497,0.01588463,0.000007127729,0.00002843009,0.003028167,0.00009287685,0.00156021,0.9744632,0.0002284595,0.004111122,0.00001146982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956317,0.0004659967,0.001362757,0.0001345395,0.00009873587,0.00001795203,0.0004440554,0.00003615076,0.001808044],"genre_scores_gemma":[0.9920033,0.0002450843,0.001585554,0.0001472602,0.000038702,0.00002058066,0.001370767,0.00003391456,0.004554892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002410718,"threshold_uncertainty_score":0.008064628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07269509757517975,"score_gpt":0.3547558427819187,"score_spread":0.282060745206739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}