{"id":"W3093094957","doi":"10.1038/s41588-020-00731-9","title":"Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor","year":2020,"lang":"en","type":"article","venue":"Nature Genetics","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":269,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Kent State University; Deutsche Forschungsgemeinschaft; National Institute on Aging; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Gene isoform; Interferon; Virology; TMPRSS2; Coronavirus; Interferon type I; Interferon-stimulated gene; Virus; Receptor; Gene; Coronavirus disease 2019 (COVID-19); Genetics; Innate immune system; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001956325,0.000244987,0.0002991149,0.00008496531,0.0001239723,0.00007932,0.0002441806,0.0004534413,0.000006231229],"category_scores_gemma":[0.0004978267,0.000165956,0.00005900484,0.0003900496,0.00023417,0.00004898096,0.0002784943,0.001453883,0.00002888351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004495965,"about_ca_system_score_gemma":0.0002017443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001926552,"about_ca_topic_score_gemma":0.00005759322,"domain_scores_codex":[0.9985121,0.00003634777,0.0002379861,0.0004374109,0.0004149921,0.000361092],"domain_scores_gemma":[0.9992015,0.0001548986,0.00006100879,0.0003399746,0.0001657033,0.00007685684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007336912,0.00006006202,0.005733084,0.0001012399,0.0001101553,0.000009788339,0.00191,7.887073e-8,0.9795619,0.00005751329,0.004198171,0.007524279],"study_design_scores_gemma":[0.001571493,0.0006673019,0.005514585,0.0000460397,0.00008042832,0.00005222194,0.0003123028,0.0005158342,0.7220675,0.00002570401,0.2689689,0.0001777202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859912,0.004314572,0.00009493891,0.008390394,0.0001728332,0.0005113833,0.00004811671,0.00006754,0.0004090408],"genre_scores_gemma":[0.8622987,0.0001332458,0.0007194997,0.1364116,0.0003641151,0.00001693007,0.000004346973,0.00003934943,0.00001221599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2647707,"threshold_uncertainty_score":0.6767489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07269509757517975,"score_gpt":0.3547558427819187,"score_spread":0.282060745206739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}