{"id":"W3093095246","doi":"10.1128/jvi.01414-20","title":"A Newly Identified Virus in the Family <i>Potyviridae</i> Encodes Two Leader Cysteine Proteases in Tandem That Evolved Contrasting RNA Silencing Suppression Functions","year":2020,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Plant Virus Research Studies","field":"Agricultural and Biological Sciences","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences; Chinese Academy of Tropical Agricultural Sciences; Chinese Academy of Agricultural Sciences; Academia Sinica; Agricultural Biotechnology Research Center, Academia Sinica; National Natural Science Foundation of China","keywords":"Biology; Proteases; RNA silencing; Potyviridae; Genetics; Gene silencing; RNA interference; RNA-induced silencing complex; RNA; Cysteine protease; Virology; Virus; Potyvirus; Cell biology; Gene; Plant virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183469,0.0003571865,0.0002784443,0.0002490083,0.0002150831,0.0003745158,0.0001836996,0.0002890644,0.0007912872],"category_scores_gemma":[0.0002207347,0.0001186657,0.0003120816,0.0001849466,0.0002208065,0.0004740287,0.0003233209,0.0005628727,0.0002388779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105367,"about_ca_system_score_gemma":0.0001614072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001616845,"about_ca_topic_score_gemma":0.000164718,"domain_scores_codex":[0.9999064,0.000006801774,0.000005855477,0.00004802638,0.00001856512,0.00001426678],"domain_scores_gemma":[0.9998077,0.00003603335,0.00007754126,0.0000217233,0.00001394539,0.00004306997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007008378,0.000009135344,0.001783995,0.00004364605,0.000007240946,0.0002269948,0.00003038869,0.00002950042,0.994567,0.0001232427,0.00004959982,0.00305917],"study_design_scores_gemma":[0.00003557489,0.0009223769,0.1061537,0.00002870444,0.0001230212,0.01579375,0.0002013069,0.001896326,0.8566231,0.0007128834,0.01747246,0.00003671305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913486,0.001536393,0.005038608,0.00009471265,0.0000445441,0.00003820159,0.0007000127,0.000106543,0.001092394],"genre_scores_gemma":[0.987923,0.0005505427,0.008266099,0.00008355145,0.00003433467,0.00002310676,0.001850877,0.00002558554,0.001242869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007912872,"threshold_uncertainty_score":0.002647102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08555747357270646,"score_gpt":0.28250989864285,"score_spread":0.1969524250701436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}