{"id":"W3093107703","doi":"10.1158/2159-8290.cd-20-1202","title":"Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; National Institutes of Health; EMBO; California Department of Fish and Game","keywords":"Biology; Cancer research; Computational biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001312346,0.00008421269,0.0001603612,0.00002606381,0.0000194008,0.000009814157,0.00008011866,0.00005846745,0.000003677577],"category_scores_gemma":[0.00009718948,0.00006551127,0.00004888479,0.0001291514,0.0001211019,0.00001145,0.0000652687,0.00004091974,1.157226e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009395979,"about_ca_system_score_gemma":0.00008332608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007664046,"about_ca_topic_score_gemma":0.0000324639,"domain_scores_codex":[0.9992647,0.00007112051,0.0002546299,0.000202712,0.0001223121,0.00008456507],"domain_scores_gemma":[0.9992988,0.00001608832,0.0003492948,0.0001500695,0.0001405341,0.00004527228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000623655,0.00006996221,0.008027037,0.00008736172,0.00004579221,4.723701e-7,0.0005721271,0.000341928,0.9717898,0.0001068003,0.00001621564,0.01831882],"study_design_scores_gemma":[0.001137166,0.0009614041,0.02544369,0.00004246458,0.0000533546,2.205142e-7,0.0002238604,0.0001789046,0.9712482,0.0001459934,0.000471663,0.00009309207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960617,0.002221057,0.0008684233,0.0001226798,0.00005879949,0.0004594567,0.00009052162,0.00000248291,0.0001149024],"genre_scores_gemma":[0.9979424,0.0009701914,0.0007639591,0.00004453233,0.0001095577,0.00004508376,0.00008701681,0.000008925656,0.00002833314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01822573,"threshold_uncertainty_score":0.2671472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588175371520535,"score_gpt":0.292363188759133,"score_spread":0.2764814350439277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}