{"id":"W3093117874","doi":"10.1016/j.lfs.2020.118564","title":"DEFA1B inhibits ZIKV replication and retards cell cycle progression through interaction with ORC1","year":2020,"lang":"en","type":"article","venue":"Life Sciences","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto General Hospital","funders":"National Key Research and Development Program of China; Chinese Academy of Medical Sciences","keywords":"Biology; Microvesicles; Viral replication; Cell biology; Flow cytometry; Cell cycle; Virology; Cell culture; Cell; Virus; Molecular biology; microRNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385831,0.000323084,0.0003361949,0.0003060382,0.0003293966,0.0004146635,0.0003242015,0.0004605629,0.002533889],"category_scores_gemma":[0.0002164869,0.0001576198,0.0003085839,0.0001596102,0.0003003402,0.0002529226,0.000219563,0.0008292869,0.0006902333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007633057,"about_ca_system_score_gemma":0.0003785991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001652975,"about_ca_topic_score_gemma":0.002141421,"domain_scores_codex":[0.999694,0.00005133797,0.00002223334,0.00004886674,0.00006683618,0.0001166569],"domain_scores_gemma":[0.9998916,0.00002344143,0.00002427992,0.00001284598,0.00001395493,0.00003374256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004852354,0.00006162886,0.0003150161,0.00007776803,0.00001997003,0.00004083758,0.000007789091,0.00008963168,0.9962283,0.0001719689,0.0003592306,0.00214262],"study_design_scores_gemma":[0.0001076297,0.0002975188,0.009624022,0.00001060426,0.00002787571,0.0003028442,0.0000375234,0.001711725,0.9780359,0.00006148677,0.009772665,0.00001022778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794901,0.00978142,0.003014446,0.0008295036,0.0001999755,0.00006058612,0.001683666,0.0001754586,0.004764761],"genre_scores_gemma":[0.9908051,0.001638762,0.001625475,0.0001886898,0.00002302872,0.00005716888,0.001647792,0.00002315526,0.003990866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002533889,"threshold_uncertainty_score":0.008476675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02056824385021579,"score_gpt":0.2985833187319376,"score_spread":0.2780150748817218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}