{"id":"W3093117874","doi":"10.1016/j.lfs.2020.118564","title":"DEFA1B inhibits ZIKV replication and retards cell cycle progression through interaction with ORC1","year":2020,"lang":"en","type":"article","venue":"Life Sciences","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto General Hospital","funders":"National Key Research and Development Program of China; Chinese Academy of Medical Sciences","keywords":"Biology; Microvesicles; Viral replication; Cell biology; Flow cytometry; Cell cycle; Virology; Cell culture; Cell; Virus; Molecular biology; microRNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409077,0.00008284267,0.00006137853,0.00001088655,0.0001341019,0.00004097347,0.0001377013,0.00004717319,0.000008567898],"category_scores_gemma":[0.000127004,0.0000629156,0.00001916984,0.0001474711,0.0002225241,0.0000239663,0.00008952589,0.00005323257,0.000007235644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003825423,"about_ca_system_score_gemma":0.00007117836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005408523,"about_ca_topic_score_gemma":0.000003210665,"domain_scores_codex":[0.9990948,0.00003917955,0.0001105441,0.0004675923,0.0001641828,0.0001236584],"domain_scores_gemma":[0.9995611,0.00000689163,0.00008835784,0.0001973163,0.00003595814,0.0001104309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141335,0.00006344153,0.0164618,0.00004831778,0.000008110588,0.000002666365,0.0004179169,0.0001708208,0.9760428,0.0001046716,0.001853692,0.004684438],"study_design_scores_gemma":[0.0003104313,0.0006983065,0.001359952,0.00003083809,0.00001537888,0.000008989243,0.0004535,0.001458032,0.9843003,0.0001851027,0.01100509,0.0001741409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928735,0.001435019,0.001081049,0.001586486,0.00003792683,0.0001529043,0.000003998651,0.00002066473,0.002808387],"genre_scores_gemma":[0.9935406,0.0001129044,0.00533668,0.0008085985,0.0001239459,0.0000118787,0.00002107613,0.000007153531,0.00003710319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01510185,"threshold_uncertainty_score":0.2565624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02056824385021579,"score_gpt":0.2985833187319376,"score_spread":0.2780150748817218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}