{"id":"W3093118262","doi":"10.1038/s41467-020-18997-2","title":"Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Bishop's University; McGill University and Génome Québec Innovation Centre; HEC Montréal; Jewish General Hospital; Université de Montréal; Institut Universitaire en Santé Mentale de Québec; Montreal Neurological Institute and Hospital; Institut Universitaire de Gériatrie de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"NIH Clinical Center; National Center for Research Resources; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institute of Biomedical Imaging and Bioengineering; Fonds de Recherche du Québec - Santé; Simons Foundation Autism Research Initiative; Fondation Brain Canada; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; University of Minnesota; Massachusetts General Hospital; Simons Foundation; Compute Canada; National Institute of Mental Health; Northwestern University; Courtois Foundation; Leon Levy Foundation; National Institutes of Health; Canada First Research Excellence Fund; U.S. Department of Health and Human Services; National Institute on Drug Abuse; Institut de Valorisation des Données; Stavros Niarchos Foundation; U.S. Department of Energy","keywords":"Schizophrenia (object-oriented programming); Copy-number variation; Functional magnetic resonance imaging; Autism spectrum disorder; Autism; Neuroscience; Insula; Attention deficit hyperactivity disorder; Thalamus; Affect (linguistics); Cognition; Resting state fMRI; Psychology; Genetics; Biology; Psychiatry; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000237857,0.0003198271,0.0002391755,0.001584684,0.0002140371,0.0003612219,0.0001558478,0.0002732114,0.001214971],"category_scores_gemma":[0.001324543,0.0001504778,0.0002428417,0.0006910112,0.0003582739,0.0001686462,0.0004350652,0.0001514732,0.00008912902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115704,"about_ca_system_score_gemma":0.0001730621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003882905,"about_ca_topic_score_gemma":0.006413619,"domain_scores_codex":[0.9998234,0.00003307573,0.00002507322,0.00005553307,0.00003151581,0.00003158969],"domain_scores_gemma":[0.9995234,0.0001380734,0.0002143953,0.0000330783,0.00002259376,0.00006842534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001249278,0.00005705054,0.8321398,0.00005537444,0.0003070066,0.001902748,0.0005870228,0.001284147,0.1476399,0.0003393666,0.0001823407,0.014256],"study_design_scores_gemma":[0.00001139284,0.00003939345,0.9956946,0.000007301491,0.00003722381,0.001263522,0.0001021703,0.000755965,0.001861457,0.0001444282,0.00007739862,0.000005090408],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996331,0.0000395575,0.0001354891,0.000006211868,5.402693e-7,0.000002175814,0.00009479844,0.000003206042,0.00008483402],"genre_scores_gemma":[0.9993997,0.00004161312,0.0002933558,0.000004726291,0.000001470842,0.000004635021,0.0002044612,0.000003220878,0.00004686361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003882905,"threshold_uncertainty_score":0.007720649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01882407642264577,"score_gpt":0.3001678593268337,"score_spread":0.2813437829041879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}