{"id":"W3093148451","doi":"10.1038/s41467-020-18936-1","title":"CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replication","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; National Transgenic Science and Technology Program; Institute of Hydrobiology; National Key Research and Development Program of China Stem Cell and Translational Research; Fundamental Research Funds for the Central Universities; Chinese Academy of Sciences; National Swine Industry Technology System; National Natural Science Foundation of China","keywords":"Japanese encephalitis; CRISPR; Biology; Subgenomic mRNA; Gene; Flavivirus; Virus; Virology; Cas9; Host (biology); Viral replication; Genetics; Computational biology; Encephalitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002671691,0.0003191841,0.0004025048,0.0002997984,0.0001824108,0.0003763764,0.0001707249,0.000339719,0.001213183],"category_scores_gemma":[0.0002591518,0.0001853378,0.0003233159,0.0001509423,0.0002097087,0.0001147635,0.0002779491,0.0003727599,0.000386181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002064744,"about_ca_system_score_gemma":0.0002346668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004785018,"about_ca_topic_score_gemma":0.0009781244,"domain_scores_codex":[0.9997004,0.00004505976,0.00003061921,0.00007278789,0.00008249781,0.00006867995],"domain_scores_gemma":[0.9998623,0.00004913303,0.00003486826,0.00001452655,0.00001396843,0.00002519301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004648924,0.00001321247,0.000380892,0.00003314357,0.000005045048,0.00006779844,0.00001427972,0.000095856,0.9975913,0.00004950345,0.00006381411,0.001638746],"study_design_scores_gemma":[0.00001454466,0.0004789185,0.0096857,0.00001325742,0.00004570261,0.0003749128,0.00005849541,0.003089757,0.9817099,0.00005835116,0.004455632,0.00001483037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740592,0.00110032,0.01875492,0.0001450212,0.00005877238,0.0001231859,0.001196093,0.0004247574,0.004137797],"genre_scores_gemma":[0.9692715,0.0009916076,0.02030462,0.0002732885,0.00001233534,0.0001348453,0.003697007,0.0001213871,0.005193289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213183,"threshold_uncertainty_score":0.00405854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03829415655618703,"score_gpt":0.3062237695146844,"score_spread":0.2679296129584974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}