{"id":"W3093148451","doi":"10.1038/s41467-020-18936-1","title":"CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replication","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; National Transgenic Science and Technology Program; Institute of Hydrobiology; National Key Research and Development Program of China Stem Cell and Translational Research; Fundamental Research Funds for the Central Universities; Chinese Academy of Sciences; National Swine Industry Technology System; National Natural Science Foundation of China","keywords":"Japanese encephalitis; CRISPR; Biology; Subgenomic mRNA; Gene; Flavivirus; Virus; Virology; Cas9; Host (biology); Viral replication; Genetics; Computational biology; Encephalitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009470358,0.0001529436,0.0003239993,0.00007310986,0.0001646524,0.00003607941,0.0006017348,0.0001567521,0.0001328369],"category_scores_gemma":[0.0008980005,0.0001249825,0.0001223996,0.0005973179,0.0001375418,0.0002621726,0.0001877032,0.0006022688,0.00000359731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001839367,"about_ca_system_score_gemma":0.00009333408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009440747,"about_ca_topic_score_gemma":0.00007613268,"domain_scores_codex":[0.9988307,0.0001167886,0.000336852,0.0002762387,0.0002850886,0.0001543562],"domain_scores_gemma":[0.9971755,0.0002767164,0.000285327,0.001822375,0.0002545395,0.0001855497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001338986,0.002005024,0.8044767,0.0003528994,0.002029705,0.00003736179,0.009105565,0.00003138318,0.1262543,0.01060405,0.03901849,0.004745626],"study_design_scores_gemma":[0.001719026,0.0002815091,0.9755909,0.0003390808,0.0006268233,0.000004819662,0.002399509,0.001487999,0.008309864,0.00003064402,0.008961133,0.0002486731],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9416589,0.01606955,0.0001456429,0.03688847,0.00004801917,0.0008506084,0.0005279608,0.0003239822,0.00348692],"genre_scores_gemma":[0.9950804,0.0004077164,0.0004410358,0.001939144,0.00005150358,0.00004137505,0.001718121,0.00003288663,0.0002878497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1711143,"threshold_uncertainty_score":0.5096641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03829415655618703,"score_gpt":0.3062237695146844,"score_spread":0.2679296129584974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}