{"id":"W3093193664","doi":"10.1038/s41467-020-19033-z","title":"SUSA2 is an F-box protein required for autoimmunity mediated by paired NLRs SOC3-CHS1 and SOC3-TN2","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Hunan Agricultural University; China Scholarship Council; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Ubiquitin ligase; Effector; F-box protein; Biology; Cell biology; Ubiquitin; Autoimmunity; Immunity; Suppressor; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161793,0.0004630876,0.0001835986,0.0002510556,0.0002052105,0.0002351515,0.0001355353,0.0002104213,0.002262362],"category_scores_gemma":[0.0001039716,0.0001171834,0.0002628862,0.0001227597,0.0002136807,0.0001153849,0.0002278861,0.0002873438,0.0006859757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002712438,"about_ca_system_score_gemma":0.0001600967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003347078,"about_ca_topic_score_gemma":0.0006315754,"domain_scores_codex":[0.9998934,0.00001841338,0.0000122232,0.00002175738,0.00003206261,0.00002209957],"domain_scores_gemma":[0.9997978,0.00002487041,0.00007238446,0.00001541223,0.0000123262,0.00007741177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006774232,0.000006424638,0.0003768218,0.00001146466,0.00000258595,0.0001055558,0.000003175998,0.00002613473,0.9991009,0.00004660015,0.00003028472,0.000222184],"study_design_scores_gemma":[0.0000559851,0.0001782362,0.03304138,0.000008814023,0.00001923954,0.003202232,0.00005367506,0.003140074,0.9569337,0.0001436829,0.003213314,0.000009663035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996609,0.0003859495,0.001543596,0.00005199105,0.00002279606,0.000009140535,0.0004538728,0.0001015883,0.0008220749],"genre_scores_gemma":[0.9974549,0.0000519836,0.000819667,0.00002240788,0.000004850072,0.000006804707,0.000710938,0.00001770785,0.0009106755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262362,"threshold_uncertainty_score":0.0075683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05468227542755958,"score_gpt":0.3295540616951801,"score_spread":0.2748717862676205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}