{"id":"W3093258005","doi":"10.3390/md18100519","title":"Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes","year":2020,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Università della Calabria; Università degli Studi di Siena","keywords":"Labdane; Diterpene; TRPV4; Chemistry; Transient receptor potential channel; Pharmacology; Biology; Stereochemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009224383,0.0001166638,0.0001522058,0.00002391405,0.0000203209,0.00001231416,0.00009264777,0.00006032547,0.00001854647],"category_scores_gemma":[0.0000685556,0.0001099913,0.00002524932,0.00008272184,0.00003856555,0.00000626986,0.0002196075,0.00004659935,5.733203e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006483002,"about_ca_system_score_gemma":0.00001384504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001029783,"about_ca_topic_score_gemma":0.000001535029,"domain_scores_codex":[0.9993269,0.00003521415,0.0001670735,0.0002749984,0.00007885187,0.0001169546],"domain_scores_gemma":[0.9997313,0.00001500696,0.00006230159,0.0001200554,0.00002046672,0.00005085809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000454366,0.00008927408,0.001126225,0.00003136543,0.00001312546,9.968088e-7,0.00007318369,0.000007391828,0.9925914,0.000002022371,0.0002926153,0.005317977],"study_design_scores_gemma":[0.0006139861,0.0001133681,0.0006221371,0.000004150514,0.000007162608,0.000002693013,0.00003522195,0.0002688618,0.9964878,0.000002905903,0.001717697,0.0001240374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984432,0.000346089,0.0000887631,0.0007302299,0.00003255429,0.0001554157,0.00002189747,0.000006934393,0.0001749082],"genre_scores_gemma":[0.9980654,0.00008073184,0.001289465,0.0001695123,0.00006697742,0.00001329027,0.0001734235,0.00001332807,0.0001278783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005193939,"threshold_uncertainty_score":0.4485316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01280200937056773,"score_gpt":0.2383556422091685,"score_spread":0.2255536328386008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}