{"id":"W3093258005","doi":"10.3390/md18100519","title":"Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane Diterpenes","year":2020,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Università della Calabria; Università degli Studi di Siena","keywords":"Labdane; Diterpene; TRPV4; Chemistry; Transient receptor potential channel; Pharmacology; Biology; Stereochemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004035242,0.0004706157,0.0005203789,0.0002759179,0.0001589412,0.0002750186,0.0004301581,0.0002942572,0.001750115],"category_scores_gemma":[0.0002609138,0.0001627322,0.0004135823,0.000249742,0.0001851412,0.0002338128,0.0002154858,0.0005824741,0.0007290131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453498,"about_ca_system_score_gemma":0.0003003809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003018913,"about_ca_topic_score_gemma":0.0006991609,"domain_scores_codex":[0.9998548,0.00003753566,0.00001587599,0.00002282398,0.00003665743,0.00003222205],"domain_scores_gemma":[0.9998814,0.00001778374,0.00002767217,0.00001727576,0.00003201773,0.00002377682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002051953,0.0001869955,0.0000784388,0.0002811714,0.00002098714,0.0001015862,0.00003155613,0.0007378015,0.9939095,0.0002071526,0.0001043693,0.004135323],"study_design_scores_gemma":[0.000104572,0.004195041,0.0005879569,0.00002495156,0.00005280814,0.0001671739,0.00003201314,0.0008097595,0.9870058,0.00006578236,0.006940718,0.00001328457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703652,0.007992349,0.01293385,0.0002060058,0.0001121447,0.001027011,0.001508504,0.0001212225,0.00573391],"genre_scores_gemma":[0.9635255,0.008677606,0.02008199,0.0001514746,0.00004840504,0.0006135876,0.0017513,0.00003600486,0.005114151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001750115,"threshold_uncertainty_score":0.005854726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01280200937056773,"score_gpt":0.2383556422091685,"score_spread":0.2255536328386008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}