{"id":"W3093283515","doi":"10.1016/j.immuni.2020.09.010","title":"CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells","year":2020,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":178,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn; Canadian Institutes of Health Research; QIMR Berghofer Medical Research Institute; Faculty of Medicine, McGill University","keywords":"Immunotherapy; Cancer research; Biology; CD8; Immune checkpoint; Cell biology; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003548862,0.0001673335,0.0002110871,0.00005548596,0.0003506285,0.00002222109,0.0004505716,0.0001050803,0.0005208],"category_scores_gemma":[0.0002118994,0.000112183,0.00009343209,0.0003953343,0.0001050164,0.0001285203,0.00009059617,0.0008055388,0.0002029646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009150123,"about_ca_system_score_gemma":0.00004471817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004213718,"about_ca_topic_score_gemma":0.00004179962,"domain_scores_codex":[0.9983565,0.0007599295,0.0003984301,0.0002053888,0.00006232574,0.0002173953],"domain_scores_gemma":[0.9988257,0.0003700161,0.0002812555,0.000441717,0.00006778809,0.0000135455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005285073,0.00009540204,0.0001497875,0.000009778688,0.00003457017,8.841769e-8,0.003063879,0.00004432006,0.9745524,0.00004300069,0.01993028,0.001547991],"study_design_scores_gemma":[0.0004973197,0.0001272468,0.001995139,0.00008946536,0.000004127753,5.887709e-7,0.002180551,0.000004730407,0.8857694,0.000005227211,0.1092192,0.0001070267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935479,0.000389954,0.00009620255,0.002463577,0.001668274,0.0004079599,0.00001510801,0.00003150462,0.001379523],"genre_scores_gemma":[0.9918994,0.00004989977,0.00004461989,0.002132542,0.00001965198,0.0000225594,0.00002992651,0.0000194208,0.005781968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08928892,"threshold_uncertainty_score":0.5702395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508133972236942,"score_gpt":0.2298753045262533,"score_spread":0.2147939648038839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}