{"id":"W3093310075","doi":"10.1002/open.202000134","title":"In vitro Selection of Chemically Modified DNAzymes","year":2020,"lang":"en","type":"review","venue":"ChemistryOpen","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Deoxyribozyme; RNA; Oligonucleotide; DNA; RNase H; Cleave; Cleavage (geology); Chemistry; Combinatorial chemistry; Nucleic acid; Primer extension; Biochemistry; Biophysics; RNase P; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000107147,0.0003542129,0.0011292,0.00004855364,0.00001889105,0.00001380312,0.0003852899,0.000561078,0.000005966386],"category_scores_gemma":[0.0001327489,0.0003128961,0.0004147669,0.0003124707,0.00008156889,0.000002870679,0.0001947107,0.0002652731,0.000002544328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005178686,"about_ca_system_score_gemma":0.0001995831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006530675,"about_ca_topic_score_gemma":0.000001307741,"domain_scores_codex":[0.9984683,0.00003868602,0.0005680323,0.0005854717,0.0001276198,0.0002119054],"domain_scores_gemma":[0.9991167,0.00001377087,0.0003775986,0.0003495297,0.00006902219,0.00007343449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004439125,0.00004399272,4.813388e-7,0.002393631,0.0001103922,0.000005461538,0.000002243872,1.824123e-7,0.8203428,0.000001281127,0.0009076457,0.1761475],"study_design_scores_gemma":[0.00007188631,0.00001601012,5.347813e-8,0.0004238205,0.00009629426,0.00001768635,0.000001637358,0.000003169818,0.5494246,0.000007092211,0.4497552,0.0001825787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002288091,0.9975174,0.000120843,0.00003207084,0.00002699272,0.0003432842,0.00007982863,0.00002993104,0.001620811],"genre_scores_gemma":[0.004795357,0.9920268,0.001443192,0.00003908296,0.0002527824,0.00004040141,0.0007792803,0.00004572631,0.0005773737],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4488475,"threshold_uncertainty_score":0.9999323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02043428575151335,"score_gpt":0.3228918043943231,"score_spread":0.3024575186428097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}