{"id":"W3093310075","doi":"10.1002/open.202000134","title":"In vitro Selection of Chemically Modified DNAzymes","year":2020,"lang":"en","type":"review","venue":"ChemistryOpen","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Deoxyribozyme; RNA; Oligonucleotide; DNA; RNase H; Cleave; Cleavage (geology); Chemistry; Combinatorial chemistry; Nucleic acid; Primer extension; Biochemistry; Biophysics; RNase P; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003579384,0.0008134744,0.0005894939,0.0007305977,0.00008592819,0.0004429845,0.0005467495,0.0005402057,0.001013569],"category_scores_gemma":[0.0003395494,0.0002969279,0.0002802155,0.0006661882,0.0002026016,0.0003553263,0.0003655813,0.0009251992,0.002446844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003868955,"about_ca_system_score_gemma":0.0002204775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002340073,"about_ca_topic_score_gemma":0.0003066346,"domain_scores_codex":[0.9996759,0.00005952555,0.0000244748,0.00007572809,0.0001321477,0.00003233139],"domain_scores_gemma":[0.9999017,0.00002918678,0.0000221171,0.000007703517,0.00002937113,0.000009973086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005712355,0.0001030013,0.0001771791,0.00564867,0.00005369194,0.0003591086,0.00006012834,0.0008179513,0.7953689,0.004934882,0.005159913,0.1872596],"study_design_scores_gemma":[0.00001863727,0.0001970705,0.0005189686,0.0003569541,0.00006186344,0.001029694,0.00001839589,0.0004170161,0.5549129,0.0005516006,0.4418851,0.00003197006],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03092438,0.8801578,0.05597602,0.0005406309,0.001462797,0.0003456673,0.0005542787,0.0004787149,0.02955984],"genre_scores_gemma":[0.1274519,0.7963187,0.0393614,0.0009598993,0.0003766006,0.0004023097,0.001728349,0.000161815,0.03323915],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001013569,"threshold_uncertainty_score":0.003390729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02043428575151335,"score_gpt":0.3228918043943231,"score_spread":0.3024575186428097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}