{"id":"W3093343668","doi":"10.1038/s41598-020-74605-9","title":"Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; National Institutes of Health","keywords":"Opioid; Hyperalgesia; δ-opioid receptor; Delta; Agonist; Migraine; Forebrain; Neuroscience; Medicine; Receptor; Pharmacology; Anesthesia; Psychology; Nociception; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645753,0.0005183484,0.0004131895,0.0004204263,0.0002035436,0.0003136517,0.0002455551,0.0003933696,0.001732521],"category_scores_gemma":[0.0001553816,0.0002725717,0.0003695625,0.0001497828,0.0004849646,0.0002931472,0.0002170822,0.001492854,0.0003513142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005322415,"about_ca_system_score_gemma":0.0003548794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195212,"about_ca_topic_score_gemma":0.002951832,"domain_scores_codex":[0.9997513,0.00003361632,0.00002475754,0.00003646891,0.00007628093,0.00007752615],"domain_scores_gemma":[0.999849,0.00001114425,0.00005965406,0.0000180082,0.00001650329,0.00004582516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005688987,0.00008731462,0.0002384963,0.00005394134,0.00001031347,0.00005228104,0.000015472,0.00005332622,0.9968792,0.0001076048,0.00007526172,0.001857949],"study_design_scores_gemma":[0.0002344542,0.002959388,0.02264581,0.00003939806,0.0001091671,0.0004760851,0.0001475734,0.001297578,0.9689019,0.0001684281,0.003003085,0.00001713146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934628,0.001970446,0.001914891,0.0003342302,0.000060631,0.00006499641,0.0005932123,0.00009069559,0.001508129],"genre_scores_gemma":[0.9902186,0.002250847,0.002023722,0.0001833866,0.00002206372,0.0001540157,0.0007218207,0.00002240921,0.004403168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001732521,"threshold_uncertainty_score":0.005795896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03796900654586888,"score_gpt":0.2753794253055304,"score_spread":0.2374104187596616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}