{"id":"W3093343919","doi":"10.1002/eji.202048869","title":"‘Nur'turing tumor T cell tolerance and exhaustion: novel function for Nuclear Receptor Nur77 in immunity","year":2020,"lang":"en","type":"review","venue":"European Journal of Immunology","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Netherlands Heart Institute; Universiteit van Amsterdam","keywords":"Nerve growth factor IB; Biology; Nuclear receptor; Cancer research; Cancer immunotherapy; Immunotherapy; T cell; T-cell receptor; Chimeric antigen receptor; Cell biology; Immune system; Immunology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006616716,0.0003339984,0.001152704,0.0002757847,0.0001949374,0.00009418857,0.0005756904,0.00008938751,0.0001707699],"category_scores_gemma":[0.0003898024,0.0002891233,0.0003314006,0.0002647694,0.0001383996,0.0001997857,0.0001872717,0.00131514,0.0001384955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001011094,"about_ca_system_score_gemma":0.00007083559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001316056,"about_ca_topic_score_gemma":1.139277e-7,"domain_scores_codex":[0.997228,0.0008899145,0.00107979,0.0003593576,0.000140253,0.0003026454],"domain_scores_gemma":[0.9981684,0.0002600802,0.00120971,0.0002072183,0.00006509133,0.00008950383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005964223,0.0002163874,9.506504e-7,0.002564648,0.00006593057,0.0002262137,0.0005128505,0.00001474983,0.07633153,0.0003463954,0.0006980965,0.9184258],"study_design_scores_gemma":[0.0009488034,0.0008005612,0.00001376679,0.003046564,0.00009794579,0.0006976298,0.00007556121,0.0000147843,0.0002856986,0.000009116943,0.9937541,0.0002554436],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004325338,0.9915901,0.0004633894,0.00008730801,0.002125992,0.0003992812,0.00001910671,0.00003454296,0.0009549639],"genre_scores_gemma":[0.003681198,0.994364,0.0009665146,0.0001773431,0.0005431732,0.000002129593,0.000003064866,0.0001543431,0.0001082518],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.993056,"threshold_uncertainty_score":0.9999561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05072949605696822,"score_gpt":0.2617609045034789,"score_spread":0.2110314084465107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}