{"id":"W3093353588","doi":"10.1016/j.cmet.2020.10.001","title":"Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty","year":2020,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Instituto de Salud Carlos III; Ministerio de Sanidad, Servicios Sociales e Igualdad; Junta de Andalucía; Ministerio de Economía y Competitividad; Federación Española de Enfermedades Raras; European Commission","keywords":"Ceramide; Endocrinology; Internal medicine; Precocious puberty; Obesity; Biology; Overweight; Adipose tissue; Delayed puberty; Kisspeptin; Hypothalamus; Medicine; Hormone; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002536158,0.0003319111,0.0007871066,0.00008595541,0.00009826765,0.0000440127,0.0002211525,0.000157146,0.0003572785],"category_scores_gemma":[0.0006361424,0.0002838369,0.0002607273,0.000248677,0.00006788733,0.0001812303,0.00009479545,0.000502227,0.0002819949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005267503,"about_ca_system_score_gemma":0.0001722524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004929013,"about_ca_topic_score_gemma":0.000002361238,"domain_scores_codex":[0.9976138,0.000125308,0.0004278347,0.0007223823,0.0004570492,0.0006536377],"domain_scores_gemma":[0.9985,0.0001167966,0.0001592176,0.0004474638,0.0001805745,0.0005959472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001995566,0.0002175166,0.007522251,0.0001307729,0.0001767374,0.0001104649,0.002603766,0.00003729042,0.9776865,0.0001138803,0.001124307,0.01007693],"study_design_scores_gemma":[0.004612369,0.0001993935,0.1543183,0.00002956567,0.0009163358,0.0000423738,0.0004198549,0.0008368522,0.7878743,0.0003578311,0.04980459,0.0005881835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798166,0.006926919,0.0003847829,0.007421024,0.0006899487,0.0007423704,0.000008764886,0.0002831869,0.00372641],"genre_scores_gemma":[0.992898,0.0001668748,0.001658911,0.001758453,0.002794023,0.00002624688,0.00002288688,0.00006964536,0.0006049406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1898122,"threshold_uncertainty_score":0.9999614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224052846930517,"score_gpt":0.2297865256510654,"score_spread":0.2073812409580137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}