{"id":"W3093353588","doi":"10.1016/j.cmet.2020.10.001","title":"Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty","year":2020,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Instituto de Salud Carlos III; Ministerio de Sanidad, Servicios Sociales e Igualdad; Junta de Andalucía; Ministerio de Economía y Competitividad; Federación Española de Enfermedades Raras; European Commission","keywords":"Ceramide; Endocrinology; Internal medicine; Precocious puberty; Obesity; Biology; Overweight; Adipose tissue; Delayed puberty; Kisspeptin; Hypothalamus; Medicine; Hormone; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002029411,0.0003441809,0.0003859949,0.0003963985,0.0004032522,0.0007145161,0.0003840147,0.0004841914,0.002768607],"category_scores_gemma":[0.0003490933,0.000224521,0.0002850922,0.0001398858,0.0006139266,0.0004369521,0.0007530503,0.001307685,0.0004485195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006272134,"about_ca_system_score_gemma":0.0005433888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008105175,"about_ca_topic_score_gemma":0.001624347,"domain_scores_codex":[0.9998572,0.00002084188,0.000006248069,0.00002853445,0.00002362034,0.00006367228],"domain_scores_gemma":[0.9997985,0.00002178792,0.00004915952,0.0000201323,0.00001875461,0.00009179951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004475069,0.0001156135,0.002272228,0.0001493738,0.00003232611,0.0006895852,0.0001150008,0.0001992884,0.9779056,0.002045849,0.0003330646,0.011667],"study_design_scores_gemma":[0.0005504576,0.00142065,0.1134136,0.0001652405,0.0001223243,0.001637048,0.0008268519,0.001923912,0.859893,0.004704151,0.01528405,0.00005863731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979183,0.008720651,0.003684206,0.0008977081,0.0002741742,0.000065013,0.000613122,0.0001035338,0.006458556],"genre_scores_gemma":[0.992664,0.002462418,0.001112873,0.0001269197,0.00006838275,0.00004525154,0.0002772863,0.00003297285,0.003209902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002768607,"threshold_uncertainty_score":0.009261906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224052846930517,"score_gpt":0.2297865256510654,"score_spread":0.2073812409580137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}