{"id":"W3093355667","doi":"10.1002/anie.202012956","title":"Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Nanjing University; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Prodrug; Drug delivery; Tumor microenvironment; Chemistry; Targeted drug delivery; Pharmacology; Cancer research; Medicine; Tumor cells; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001817462,0.0003970041,0.0002536874,0.0001759095,0.00009193952,0.0002076442,0.00020538,0.0003515183,0.0006950668],"category_scores_gemma":[0.0001354518,0.0001965676,0.0002131898,0.0001401777,0.0001748788,0.0003642824,0.0001826719,0.0003894796,0.000575288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002611096,"about_ca_system_score_gemma":0.0002240125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000214306,"about_ca_topic_score_gemma":0.000271761,"domain_scores_codex":[0.9998875,0.00001378401,0.000009531628,0.00003515174,0.00003487459,0.00001908467],"domain_scores_gemma":[0.9999452,0.000009641129,0.00002258763,0.000005918127,0.000008486522,0.000008310681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002486973,0.00001594792,0.00003286096,0.00004987419,0.000004354942,0.00003729406,0.00000709657,0.0001893459,0.9928,0.0002328768,0.0001297388,0.006475708],"study_design_scores_gemma":[0.000006048356,0.0000949204,0.0001673847,0.000001727876,0.000007227374,0.0001080279,0.000001766547,0.00173765,0.9951066,0.0000195125,0.002743426,0.000005650542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6921783,0.01448876,0.2777839,0.0006793643,0.000313855,0.0003986505,0.0007891,0.002833649,0.01053437],"genre_scores_gemma":[0.8704737,0.004318792,0.1162711,0.0003602851,0.00007020521,0.0001729953,0.0004954009,0.00008529046,0.007752081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006950668,"threshold_uncertainty_score":0.002325296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009708879103226126,"score_gpt":0.2201008713407566,"score_spread":0.2103919922375305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}