{"id":"W3093402173","doi":"10.7554/elife.58914","title":"Effects of lifelong testosterone exposure on health and disease using Mendelian randomization","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Impact; Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"Medical Research Council; Canadian Institutes of Health Research; Canada Research Chairs; McMaster University; Cisco Systems","keywords":"Mendelian randomization; Testosterone (patch); Disease; Biology; Genetics; Mendelian inheritance; Medicine; Physiology; Computational biology; Psychology; Bioinformatics; Internal medicine; Gene; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007243673,0.000071265,0.0002526756,0.00002632009,0.00005187848,0.00000228202,0.00001280234,0.00001286291,0.000001377542],"category_scores_gemma":[0.0008039164,0.00004947893,0.00002645857,0.00008392125,0.00003962452,0.00002131784,0.0000210546,0.00005087857,0.000001849838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001205458,"about_ca_system_score_gemma":0.0000716336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006595714,"about_ca_topic_score_gemma":3.0139e-7,"domain_scores_codex":[0.99942,0.00004215247,0.0001338208,0.0001629352,0.0001602515,0.0000807641],"domain_scores_gemma":[0.999499,0.000047839,0.00005617937,0.00005998472,0.00005082717,0.000286215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05938235,0.002249883,0.4716066,0.01976,0.001707247,0.0003528996,0.04099557,0.0008026478,0.2714141,0.0006808745,0.02415232,0.1068955],"study_design_scores_gemma":[0.06575941,0.01152721,0.8187554,0.0030778,0.0007948614,0.00001822651,0.002226873,0.003446229,0.08701237,0.0001348539,0.006511043,0.0007357096],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669901,0.00876481,0.000321309,0.02331268,0.00005588292,0.0004794172,0.000003354379,0.00002264108,0.00004982885],"genre_scores_gemma":[0.9948137,0.0004327438,0.0002234956,0.004200665,0.0002901555,0.000004481828,0.000004780412,0.000008535159,0.00002140978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3471488,"threshold_uncertainty_score":0.2017692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787962523809956,"score_gpt":0.2831882390249316,"score_spread":0.2553086137868321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}