{"id":"W3093402173","doi":"10.7554/elife.58914","title":"Effects of lifelong testosterone exposure on health and disease using Mendelian randomization","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Impact; Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"Medical Research Council; Canadian Institutes of Health Research; Canada Research Chairs; McMaster University; Cisco Systems","keywords":"Mendelian randomization; Testosterone (patch); Disease; Biology; Genetics; Mendelian inheritance; Medicine; Physiology; Computational biology; Psychology; Bioinformatics; Internal medicine; Gene; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06916739,0.001760919,0.003359596,0.002148818,0.0007397118,0.001404938,0.001736704,0.002104137,0.009116264],"category_scores_gemma":[0.08960594,0.0007707293,0.003990961,0.001934415,0.001924543,0.001406015,0.001357275,0.001563811,0.0004535943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001137595,"about_ca_system_score_gemma":0.001335545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003236225,"about_ca_topic_score_gemma":0.001767935,"domain_scores_codex":[0.8896732,0.09664863,0.002751291,0.006378251,0.003401791,0.001146845],"domain_scores_gemma":[0.9533309,0.03380293,0.003348913,0.008410592,0.0007985033,0.0003082335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2329948,0.002305005,0.1480208,0.006257035,0.1057787,0.006788075,0.002239154,0.03095857,0.0116678,0.1681779,0.01732938,0.2674829],"study_design_scores_gemma":[0.08894372,0.03351963,0.09892856,0.001550235,0.07666295,0.00664661,0.0006330954,0.3215958,0.01234834,0.3131621,0.04532962,0.0006792595],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4384306,0.006912894,0.5209639,0.002971359,0.001588851,0.01508574,0.004242306,0.002153022,0.007651307],"genre_scores_gemma":[0.8089784,0.001111247,0.1726554,0.0009332672,0.0002239547,0.01231319,0.0008483446,0.0001443594,0.002791976],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.06916739,"threshold_uncertainty_score":0.3657965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02787962523809956,"score_gpt":0.2831882390249316,"score_spread":0.2553086137868321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}