{"id":"W3093406532","doi":"10.1101/2020.10.15.338855","title":"DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Health and Medical Research Council; Medical Research Council; Cancer Institute NSW","keywords":"Replication timing; Biology; Genetics; Epigenome; DNA methylation; DNA replication; Genome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683117,0.0002633556,0.0002643502,0.0002031787,0.0002117034,0.0004490688,0.000261437,0.0004406642,0.001787287],"category_scores_gemma":[0.0002629127,0.0002989438,0.00020891,0.0001397799,0.0003155413,0.0002428901,0.0004964912,0.0005393583,0.0009553209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004395829,"about_ca_system_score_gemma":0.0002833682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001378139,"about_ca_topic_score_gemma":0.001393145,"domain_scores_codex":[0.9998461,0.00001594477,0.000009909176,0.00004676848,0.0000526839,0.00002853716],"domain_scores_gemma":[0.9998246,0.00001823464,0.00005921995,0.00004389658,0.00002273791,0.00003136985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002666427,0.000002612337,0.0002592251,0.00001450125,0.000002203286,0.0000230932,0.000005816028,0.00009741032,0.9986749,0.0001418224,0.00004120413,0.0007105423],"study_design_scores_gemma":[0.000005636943,0.00003074098,0.007575769,0.000003600062,0.000004692809,0.0001324054,0.00001166756,0.002465704,0.9867238,0.0001953743,0.002844752,0.000005809426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638532,0.001937853,0.0286703,0.0002670543,0.00008835067,0.00002634686,0.00108354,0.0006946525,0.00337863],"genre_scores_gemma":[0.9860994,0.0003901716,0.007826986,0.00004805891,0.0000117242,0.00001558556,0.0007441995,0.0001200624,0.004743749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001787287,"threshold_uncertainty_score":0.005979002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03077543950297743,"score_gpt":0.2732588374902702,"score_spread":0.2424833979872928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}