{"id":"W3093412637","doi":"10.1126/science.aaz0863","title":"The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids","year":2020,"lang":"en","type":"article","venue":"Science","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Genome Canada","keywords":"mTORC1; Lysosome; Cell biology; GTPase; Amino acid; Chemistry; Small GTPase; Biology; Signal transduction; Biochemistry; PI3K/AKT/mTOR pathway; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588756,0.00008952106,0.00005247812,0.00001261927,0.0002257519,0.0000638682,0.0003001151,0.00004180117,0.00000500455],"category_scores_gemma":[0.0002294023,0.00006901873,0.0000289856,0.0002304545,0.0001961883,0.000007818628,0.0001261301,0.00006185369,0.00001113537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000115374,"about_ca_system_score_gemma":0.00009173229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002290429,"about_ca_topic_score_gemma":0.000001620404,"domain_scores_codex":[0.999171,0.00001266336,0.0001013988,0.0002923032,0.0001923004,0.000230298],"domain_scores_gemma":[0.9995642,0.00000943422,0.0000320081,0.0002081065,0.0000572512,0.0001289688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007577062,0.000005088235,0.0002262009,0.000003217131,0.000002333783,2.584217e-7,0.00009457979,0.00009889963,0.9958712,0.00002798051,0.0006951668,0.002967496],"study_design_scores_gemma":[0.000120295,0.0000790665,0.001035562,0.000003326049,0.000001488117,0.000001210028,0.00009394829,0.0003641352,0.953568,0.00001138492,0.04462577,0.00009585851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857265,0.0003994347,0.01242179,0.0007929443,0.0001178997,0.00009890175,0.000006382476,0.00001915608,0.0004170019],"genre_scores_gemma":[0.9990593,0.00004767182,0.0001498302,0.000456461,0.0001277956,0.000008922882,0.000009814845,0.0000080795,0.000132111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0439306,"threshold_uncertainty_score":0.2814502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00747759065100929,"score_gpt":0.2579841935871065,"score_spread":0.2505066029360972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}