{"id":"W3093444206","doi":"10.1002/pro.3979","title":"Biosynthesis of depsipeptides, <i>or</i> Depsi: The peptides with varied generations","year":2020,"lang":"en","type":"review","venue":"Protein Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Depsipeptide; Moiety; Nonribosomal peptide; Stereochemistry; Peptide; Chemistry; Peptide bond; Combinatorial chemistry; Biosynthesis; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638086,0.0005794129,0.0005329237,0.001321905,0.0001208838,0.0004983518,0.0003345148,0.0004780384,0.001906214],"category_scores_gemma":[0.0001983173,0.0001830891,0.0002503958,0.001022131,0.0001927414,0.0007056947,0.0003630583,0.0006691419,0.001669798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003110325,"about_ca_system_score_gemma":0.0003779918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003508436,"about_ca_topic_score_gemma":0.0005933387,"domain_scores_codex":[0.9999342,0.000007659163,0.000009671393,0.00001650254,0.00002227298,0.000009718362],"domain_scores_gemma":[0.9999431,0.00001910162,0.0000143956,0.000002566762,0.00001149224,0.000009357395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001221528,0.00007925766,0.000254845,0.01602014,0.00008402599,0.0003098931,0.00004543504,0.0004628769,0.02153745,0.004171944,0.009395933,0.9475161],"study_design_scores_gemma":[0.00001487362,0.0001495695,0.0008766685,0.001074181,0.00008615972,0.001603039,0.00002730021,0.0001640591,0.009627673,0.0008455765,0.9855143,0.00001661286],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009391203,0.9959359,0.0004093148,0.0001061406,0.0001330305,0.000007843561,0.00004332214,0.00001877249,0.002406556],"genre_scores_gemma":[0.004392583,0.9932428,0.0004565934,0.000144829,0.0001008288,0.00001141097,0.0001157494,0.000003814288,0.001531465],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001906214,"threshold_uncertainty_score":0.006376922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05854007347887794,"score_gpt":0.3132878322036898,"score_spread":0.2547477587248119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}