{"id":"W3093456436","doi":"10.1073/pnas.2006076117","title":"Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; Damon Runyon Cancer Research Foundation","keywords":"PRC2; Histone methyltransferase; Histone H3; EZH2; Histone; Cancer research; Biology; Histone methylation; Missense mutation; Mutation; Genetics; Gene; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006142,0.000186727,0.0001141814,0.000225098,0.0001166816,0.0001857089,0.0001193966,0.0001897489,0.0008112071],"category_scores_gemma":[0.0001142025,0.0001258333,0.0001415399,0.0001393279,0.0001944833,0.00007732302,0.0002004445,0.0002853239,0.0001920443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512795,"about_ca_system_score_gemma":0.000198664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203038,"about_ca_topic_score_gemma":0.002201237,"domain_scores_codex":[0.9999161,0.00001408378,0.000007227192,0.00001516973,0.00002340485,0.00002407881],"domain_scores_gemma":[0.9999239,0.00001272995,0.0000288977,0.000008564893,0.000005639511,0.00002025292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008099636,0.00001238701,0.002657113,0.000009585713,0.000007002819,0.000127818,0.0000100639,0.0001115404,0.9954045,0.0001296174,0.00004528387,0.001403997],"study_design_scores_gemma":[0.00002968792,0.000210974,0.0362473,0.000003419508,0.00002240175,0.001681625,0.00003439759,0.001486389,0.9578591,0.0002274358,0.002193093,0.000004197111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972308,0.00039978,0.001313717,0.00005252626,0.00000423533,0.00001123098,0.0001044675,0.0000860976,0.0007971408],"genre_scores_gemma":[0.9988937,0.0001376617,0.000513381,0.0000180206,0.000001436467,0.000005139791,0.00006499917,0.000007247244,0.0003585244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203038,"threshold_uncertainty_score":0.002713799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03307502034737968,"score_gpt":0.3330991345573112,"score_spread":0.3000241142099315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}