{"id":"W3093456436","doi":"10.1073/pnas.2006076117","title":"Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression","year":2020,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; Damon Runyon Cancer Research Foundation","keywords":"PRC2; Histone methyltransferase; Histone H3; EZH2; Histone; Cancer research; Biology; Histone methylation; Missense mutation; Mutation; Genetics; Gene; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003553224,0.00006594354,0.00008227534,0.0000317155,0.0001334461,0.00001297732,0.0002045461,0.00005333815,0.000002227694],"category_scores_gemma":[0.0003703023,0.00004612358,0.00003548471,0.0002098885,0.000447359,0.0000190445,0.0001119334,0.00007080762,2.365125e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006869368,"about_ca_system_score_gemma":0.00003170944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002000726,"about_ca_topic_score_gemma":7.83397e-8,"domain_scores_codex":[0.9991472,0.000006598371,0.0001492121,0.0002172097,0.0003976361,0.00008209608],"domain_scores_gemma":[0.9995134,0.0000131715,0.0002620045,0.000005970115,0.0001648473,0.00004062735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000164924,0.00002396788,0.002595837,0.00003013379,0.000006426953,3.198224e-9,0.0001494748,0.0000294636,0.9953266,0.0006203305,0.00005580922,0.001145467],"study_design_scores_gemma":[0.0001270588,0.0001400723,0.03982219,0.00002340645,0.000006920372,0.000001385552,0.0000367075,0.001180636,0.955163,0.00292571,0.000516232,0.00005664726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951684,0.0003751413,0.00001334102,0.003385647,0.000008277755,0.0001865391,0.000008297347,0.0000039513,0.0008503931],"genre_scores_gemma":[0.9974131,0.00005825563,0.002314633,0.0001084965,0.00006126321,0.000008854007,4.999271e-7,0.000003488567,0.00003138063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04016356,"threshold_uncertainty_score":0.1880865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03307502034737968,"score_gpt":0.3330991345573112,"score_spread":0.3000241142099315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}