{"id":"W3093529184","doi":"10.14309/01.ajg.0000714848.73122.58","title":"S3200 ABP 710, a Biosimilar to Infliximab Reference Product: Supporting Extrapolation of Indications With a Focus on Crohn’s Disease","year":2020,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Antibody-dependent cell-mediated cytotoxicity; Infliximab; Immunology; Peripheral blood mononuclear cell; Tumor necrosis factor alpha; Immune system; Pharmacology; Antibody; Monoclonal antibody; Biology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00236328,0.0003610997,0.0002458971,0.0004713871,0.0001551104,0.0008843008,0.0003546956,0.0008589935,0.003484418],"category_scores_gemma":[0.003093485,0.00009046775,0.0002623058,0.000337782,0.0004277073,0.0003472829,0.0003253394,0.0007165532,0.00119651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004363273,"about_ca_system_score_gemma":0.0009646546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005548431,"about_ca_topic_score_gemma":0.0004578461,"domain_scores_codex":[0.9991665,0.0002814793,0.000074403,0.00008761717,0.0003466969,0.00004332003],"domain_scores_gemma":[0.9983544,0.0005701282,0.0002808471,0.0001095765,0.0005083816,0.0001766336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00955052,0.000761208,0.02426386,0.002375051,0.00007414733,0.002782411,0.0003709909,0.001697732,0.4809401,0.00360924,0.009582965,0.4639918],"study_design_scores_gemma":[0.003635781,0.04674742,0.1421714,0.002368777,0.0005366079,0.0283546,0.0006050543,0.008797915,0.3400187,0.005171504,0.4214796,0.000112757],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.909799,0.03956736,0.01060116,0.004868089,0.000494388,0.0003788414,0.001610988,0.0003003661,0.03237994],"genre_scores_gemma":[0.9725052,0.008896417,0.01034824,0.001884818,0.0003794335,0.00009166699,0.00324832,0.00004844785,0.002597403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003484418,"threshold_uncertainty_score":0.01249838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02350239903314753,"score_gpt":0.288266643963435,"score_spread":0.2647642449302875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}