{"id":"W3093534882","doi":"10.14309/01.ajg.0000704640.35342.ed","title":"S0648 Clinically Adjusted vs Therapeutic Drug Monitoring Dosing Regimens With Adalimumab in Patients With Moderately to Severely Active Crohn's Disease: Results From the SERENE-CD Maintenance Study","year":2020,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Dosing; Therapeutic drug monitoring; Adalimumab; Maintenance therapy; Internal medicine; Maintenance dose; Clinical trial; Demographics; Gastroenterology; Surgery; Pharmacokinetics; Disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00350946,0.0007413088,0.002058541,0.0003460022,0.0002784084,0.001006866,0.0005550457,0.001135407,0.00295374],"category_scores_gemma":[0.002199822,0.000263984,0.002654258,0.0005133242,0.0005550592,0.0008281652,0.0003373708,0.002122914,0.0006202709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004229951,"about_ca_system_score_gemma":0.0005605486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003468731,"about_ca_topic_score_gemma":0.0006967816,"domain_scores_codex":[0.9986708,0.0007940723,0.0001350714,0.0001375176,0.0001737379,0.0000887479],"domain_scores_gemma":[0.9982925,0.0005633164,0.0004663562,0.0001913922,0.0001358727,0.0003504837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8891628,0.01247783,0.01272639,0.0007939041,0.002575136,0.00006799817,0.0001290423,0.000555622,0.004269918,0.00009686533,0.001116913,0.0760275],"study_design_scores_gemma":[0.3868396,0.5418583,0.06302384,0.0001812179,0.002231611,0.0002069463,0.00007748484,0.000712016,0.001033098,0.0001623928,0.003627695,0.00004590751],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844977,0.01106729,0.0002494458,0.000371605,0.0001376275,0.0005387167,0.001037603,0.00003305859,0.002066826],"genre_scores_gemma":[0.9906344,0.003907692,0.0007120832,0.0007999965,0.0003213879,0.0004337901,0.002046616,0.00001373217,0.001130375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00350946,"threshold_uncertainty_score":0.01856005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163791257873487,"score_gpt":0.2413722944296648,"score_spread":0.22973438185093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}