{"id":"W3093545770","doi":"10.1002/1873-3468.13962","title":"Structural plasticity of substrate selection by activation‐induced cytidine deaminase as a regulator of its genome‐wide mutagenic activity","year":2020,"lang":"en","type":"article","venue":"FEBS Letters","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Memorial University of Newfoundland","funders":"Institute of Infection and Immunity; Natural Sciences and Engineering Research Council of Canada","keywords":"Cytidine deaminase; Regulator; Activation-induced (cytidine) deaminase; Cytidine; Substrate specificity; Substrate (aquarium); Chemistry; Genome; Selection (genetic algorithm); Biology; Biochemistry; Genetics; Enzyme; Cell biology; Computational biology; Biophysics; Gene; Somatic hypermutation; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000359545,0.0001330108,0.0001544247,0.00002661505,0.00002973847,0.000006167864,0.00009753274,0.00007971133,0.00002007457],"category_scores_gemma":[0.0001012397,0.0001410801,0.00006977836,0.0001236024,0.00002447474,0.000006752489,0.00003512275,0.00008314594,0.000001422653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001583932,"about_ca_system_score_gemma":0.00003226317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002298175,"about_ca_topic_score_gemma":0.000004990357,"domain_scores_codex":[0.9993033,0.00002657305,0.0001691196,0.0002307423,0.0001157096,0.0001545232],"domain_scores_gemma":[0.9996538,0.00001528142,0.0001114303,0.00009707062,0.00004826368,0.0000742132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001561542,0.00001119438,0.0007503096,0.00006578011,0.00005926178,6.74141e-7,0.00006446827,0.004213009,0.9943109,0.00000201793,0.0002006596,0.0001655545],"study_design_scores_gemma":[0.0003659009,0.0002120754,0.03120646,0.000006739912,0.00002034698,0.000003301768,0.00001402221,0.001204908,0.9667023,9.816634e-7,0.0001355655,0.0001274403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918005,0.00004050784,0.007432273,0.000494724,0.00003683258,0.0001430457,0.00002769076,0.00001132605,0.00001307415],"genre_scores_gemma":[0.9994221,0.000008310692,0.0001455388,0.0002500548,0.0000928629,0.000005047036,0.00004427532,0.00001692635,0.00001493958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03045615,"threshold_uncertainty_score":0.575308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009621508241413182,"score_gpt":0.2480162277420667,"score_spread":0.2383947195006535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}