{"id":"W3093545770","doi":"10.1002/1873-3468.13962","title":"Structural plasticity of substrate selection by activation‐induced cytidine deaminase as a regulator of its genome‐wide mutagenic activity","year":2020,"lang":"en","type":"article","venue":"FEBS Letters","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Memorial University of Newfoundland","funders":"Institute of Infection and Immunity; Natural Sciences and Engineering Research Council of Canada","keywords":"Cytidine deaminase; Regulator; Activation-induced (cytidine) deaminase; Cytidine; Substrate specificity; Substrate (aquarium); Chemistry; Genome; Selection (genetic algorithm); Biology; Biochemistry; Genetics; Enzyme; Cell biology; Computational biology; Biophysics; Gene; Somatic hypermutation; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016901,0.0002101236,0.0002050892,0.0001311015,0.0001502327,0.0004832812,0.0002173112,0.0002928771,0.0009063558],"category_scores_gemma":[0.0003957355,0.0001598634,0.0001070333,0.0001058763,0.0002838425,0.0001466553,0.0002099037,0.0004003549,0.000329879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002773863,"about_ca_system_score_gemma":0.0001578495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003397797,"about_ca_topic_score_gemma":0.0004633116,"domain_scores_codex":[0.999873,0.00002461226,0.000008108858,0.00003022294,0.00003732135,0.00002669196],"domain_scores_gemma":[0.9998023,0.00007351185,0.00003943021,0.000021993,0.00002499255,0.0000377074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003200854,0.000008431451,0.0003445794,0.000007896193,0.000002365792,0.00005641017,0.000009806563,0.0002454343,0.9980114,0.0001585476,0.00002534314,0.001097767],"study_design_scores_gemma":[0.00001101728,0.0001036994,0.009093842,0.000003158737,0.000009190316,0.0004772317,0.00004132864,0.0100731,0.9786331,0.0002502251,0.001292179,0.00001194542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995014,0.0003126998,0.003076255,0.00008769341,0.00001331611,0.000006660807,0.00004504339,0.0001211072,0.001323125],"genre_scores_gemma":[0.9990508,0.0000698261,0.0005223129,0.00001948356,0.000002107671,0.000003234532,0.00002958583,0.00001346201,0.0002891166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009063558,"threshold_uncertainty_score":0.003032029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009621508241413182,"score_gpt":0.2480162277420667,"score_spread":0.2383947195006535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}