{"id":"W3093553483","doi":"10.1074/jbc.ra120.015680","title":"BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; American Heart Association; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Transcytosis; Cell biology; Internalization; Bone morphogenetic protein receptor; Endocytosis; Chemistry; Endothelial stem cell; LDL receptor; BMPR2; Bone morphogenetic protein; Biology; Receptor; Lipoprotein; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263704,0.0002092728,0.0002629105,0.0001606005,0.0002080911,0.0004524301,0.0001744079,0.0003312401,0.001007833],"category_scores_gemma":[0.00006283351,0.0001741253,0.0003031837,0.0001079983,0.0001459353,0.000250089,0.0002482549,0.000694639,0.0003888934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004066493,"about_ca_system_score_gemma":0.0002372939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007972076,"about_ca_topic_score_gemma":0.0008513838,"domain_scores_codex":[0.9997836,0.00003144668,0.00001644805,0.00003694443,0.00005534539,0.00007626746],"domain_scores_gemma":[0.9999492,0.000005972765,0.00001220042,0.000003448724,0.0000109828,0.00001819137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009950719,0.0000239536,0.0002277121,0.00003052609,0.00000514459,0.00004148429,0.00001234027,0.00004209487,0.9985629,0.0001776256,0.0000375623,0.0007391849],"study_design_scores_gemma":[0.00001865361,0.00009594665,0.007925619,0.000007667746,0.00002279322,0.0001773791,0.00006833262,0.001865378,0.9873928,0.00009472093,0.002324792,0.000005913896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920162,0.002849353,0.002533273,0.0001405565,0.00004943719,0.00002239184,0.0002421212,0.00004853071,0.002098075],"genre_scores_gemma":[0.9942426,0.001104469,0.001233716,0.0001147074,0.00001148517,0.00003055287,0.0002802779,0.00001088066,0.002971236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001007833,"threshold_uncertainty_score":0.003371537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458303248865909,"score_gpt":0.2221926215465043,"score_spread":0.2076095890578452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}