{"id":"W3093579997","doi":"10.3389/fimmu.2020.594136","title":"Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Robarts Research Institute; Canadian Institutes of Health Research; Arthritis Society; Ontario Ministry of Research and Innovation; Heart and Stroke Foundation of Canada","keywords":"Efferocytosis; Phagolysosome; Cell biology; GATA2; Haematopoiesis; Biology; Macrophage; Transcriptome; Transcription factor; Apoptosis; Phagocytosis; Cancer research; Immunology; Chemistry; In vitro; Gene expression; Genetics; Gene; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003328593,0.0004640106,0.0003472253,0.0003691797,0.0002083842,0.0003433597,0.0002592638,0.0005173003,0.001458855],"category_scores_gemma":[0.0002138763,0.0002927592,0.0003564018,0.0001588292,0.0004419858,0.0001859147,0.0004515159,0.0008055403,0.0006304381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002566352,"about_ca_system_score_gemma":0.0001841844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004025677,"about_ca_topic_score_gemma":0.0005617276,"domain_scores_codex":[0.999674,0.00005831757,0.00004192893,0.00007506542,0.00008027894,0.00007040932],"domain_scores_gemma":[0.9996921,0.00005468297,0.00009520105,0.00004366789,0.00002561671,0.00008878412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006238904,0.00001156089,0.0001198417,0.00001094176,0.000001881445,0.00009219755,0.00001201335,0.00002033277,0.9993988,0.00006343773,0.00001267913,0.0001938397],"study_design_scores_gemma":[0.00003704254,0.0002201495,0.007925254,0.0000110946,0.00002050281,0.001059796,0.00004907035,0.001280894,0.9873812,0.0001496075,0.001855713,0.000009639432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931212,0.0006782253,0.004597684,0.0001011543,0.00004104845,0.00003282564,0.0005435166,0.0001465666,0.0007378117],"genre_scores_gemma":[0.9935213,0.0004125405,0.002691544,0.00007387152,0.0000149882,0.00004836663,0.0005461407,0.00007465923,0.002616477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001458855,"threshold_uncertainty_score":0.004880369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009572534585333711,"score_gpt":0.2076386216733918,"score_spread":0.1980660870880581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}