{"id":"W3093612331","doi":"10.1016/j.chembiol.2020.10.001","title":"Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors","year":2020,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Congressionally Directed Medical Research Programs; National Cancer Institute; National Institutes of Health; Ludwig Center at Harvard; Deutsche Forschungsgemeinschaft; Novartis Pharma; Deutschen Konsortium für Translationale Krebsforschung; Ono Pharma Foundation; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Broad Institute; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Shenzhen Gas Corporation; Wellcome Trust; U.S. Department of Defense; Genome Canada; Merck KGaA; Meso Scale Diagnostics; Cancer Prevention and Research Institute of Texas; Takeda Pharmaceuticals U.S.A.; Pfizer; Alexander and Margaret Stewart Trust; Boehringer Ingelheim; Janssen Pharmaceuticals; Prostate Cancer Foundation; National Science Foundation","keywords":"Androgen receptor; Prostate cancer; Cancer research; Transcription (linguistics); Transcription factor; In vivo; Androgen; Biology; Chemistry; Cancer; Endocrinology; Gene; Hormone; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003555165,0.0001268713,0.0002428461,0.00003916947,0.00002333717,0.000004519779,0.00004643005,0.0001069253,0.0000717608],"category_scores_gemma":[0.00001454982,0.00008774624,0.0000379852,0.0002850937,0.0001162512,0.00003321132,0.00001952392,0.0002871878,0.000009694773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000165364,"about_ca_system_score_gemma":0.0001140563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007115639,"about_ca_topic_score_gemma":0.000006482797,"domain_scores_codex":[0.9990948,0.00003395995,0.0001547805,0.0003398581,0.00007935831,0.0002972108],"domain_scores_gemma":[0.9996694,0.00002099345,0.00003598346,0.00006240684,0.00006045413,0.0001507249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001231828,0.00006196772,0.1199372,0.0000780063,0.0000316251,0.00001503307,0.001159832,0.00001971909,0.8750868,0.000003257927,0.0001834875,0.00219126],"study_design_scores_gemma":[0.003224203,0.0006173696,0.0004775617,0.00005432767,0.00002368465,0.000003190937,0.000135622,0.0005946726,0.9937994,0.00002189367,0.0009309849,0.0001170973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954617,0.0008402107,0.00001563037,0.002324566,0.00002571637,0.0005061362,0.00002133058,0.00003968095,0.0007650088],"genre_scores_gemma":[0.9985502,0.0002437832,0.0004322071,0.0002583739,0.0001436493,0.0001060804,0.0001663742,0.00001731455,0.00008205447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1194596,"threshold_uncertainty_score":0.3578188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02230250501219739,"score_gpt":0.2829229771604266,"score_spread":0.2606204721482293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}