{"id":"W3093612331","doi":"10.1016/j.chembiol.2020.10.001","title":"Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors","year":2020,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Congressionally Directed Medical Research Programs; National Cancer Institute; National Institutes of Health; Ludwig Center at Harvard; Deutsche Forschungsgemeinschaft; Novartis Pharma; Deutschen Konsortium für Translationale Krebsforschung; Ono Pharma Foundation; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Broad Institute; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Shenzhen Gas Corporation; Wellcome Trust; U.S. Department of Defense; Genome Canada; Merck KGaA; Meso Scale Diagnostics; Cancer Prevention and Research Institute of Texas; Takeda Pharmaceuticals U.S.A.; Pfizer; Alexander and Margaret Stewart Trust; Boehringer Ingelheim; Janssen Pharmaceuticals; Prostate Cancer Foundation; National Science Foundation","keywords":"Androgen receptor; Prostate cancer; Cancer research; Transcription (linguistics); Transcription factor; In vivo; Androgen; Biology; Chemistry; Cancer; Endocrinology; Gene; Hormone; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005563,0.0003008543,0.0002560982,0.0001998247,0.0001062687,0.0002445196,0.000180794,0.00009634419,0.001153357],"category_scores_gemma":[0.00006529163,0.0001340299,0.0001556536,0.0001905109,0.0001300285,0.00009589296,0.0001060957,0.0004399712,0.000301702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174555,"about_ca_system_score_gemma":0.0002870899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009535244,"about_ca_topic_score_gemma":0.004720665,"domain_scores_codex":[0.9999357,0.00001075665,0.000004719054,0.00001237766,0.00001717708,0.00001913692],"domain_scores_gemma":[0.9999717,0.000006814815,0.000006076061,0.000003534657,0.000003576377,0.000008190204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002071587,0.0001267139,0.0001993566,0.00007161787,0.00001118952,0.00002291229,0.000009822465,0.000442393,0.992053,0.0002004145,0.0001494951,0.00650575],"study_design_scores_gemma":[0.00007063744,0.001006211,0.001748068,0.000004492038,0.00001900555,0.0001528988,0.00001136377,0.001381146,0.9916142,0.00003990357,0.003946051,0.000005910002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854676,0.006057527,0.003749346,0.0001350987,0.00004112645,0.0000942284,0.0007724647,0.0002022784,0.003480301],"genre_scores_gemma":[0.9908756,0.00352792,0.002951932,0.00005135704,0.000009571302,0.00005011767,0.0006137802,0.00002314159,0.001896561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153357,"threshold_uncertainty_score":0.003858328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02230250501219739,"score_gpt":0.2829229771604266,"score_spread":0.2606204721482293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}