{"id":"W3093618934","doi":"10.1093/braincomms/fcaa177","title":"Grey matter network trajectories across the Alzheimer’s disease continuum and relation to cognition","year":2020,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Pfizer; Biogen; BioClinica; Alzheimer Nederland; Eisai; Amsterdam Neuroscience; ZonMw; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cognitive decline; Dementia; Cognition; Disease; Grey matter; Psychology; Alzheimer's disease; Cognitive reserve; Mini–Mental State Examination; Neuroscience; Medicine; Cognitive impairment; Pathology; White matter; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398529,0.00008336794,0.000102065,0.00001594759,0.0004742022,0.00009137204,0.0001941157,0.00002674273,0.0001357473],"category_scores_gemma":[0.0003485473,0.00006451277,0.00004142072,0.0002567252,0.0001898216,0.0001093646,0.000275007,0.0001934747,0.0001803028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009045432,"about_ca_system_score_gemma":0.00004096849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001181626,"about_ca_topic_score_gemma":0.00004386983,"domain_scores_codex":[0.9991356,0.0001897476,0.0001613806,0.0001506204,0.000166867,0.0001957413],"domain_scores_gemma":[0.9986612,0.00039803,0.00003811477,0.0004961119,0.000171953,0.0002345862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006608839,0.0002456995,0.8143039,0.00005429843,0.000311683,0.000009230276,0.007142411,0.000005354838,0.001140214,0.002062627,0.157357,0.01670672],"study_design_scores_gemma":[0.0005888619,0.00009784295,0.9439734,0.00004361589,0.0001482299,0.000004769828,0.000603919,0.0003645012,0.00004123269,0.0004729929,0.05358469,0.00007597253],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.3238332,0.001763307,0.001169273,0.6631426,0.00004344298,0.001615044,0.00006313197,0.00008541172,0.008284644],"genre_scores_gemma":[0.9792254,0.00009205357,0.0005003427,0.01926046,0.0001225488,0.0001947282,0.0001893732,0.00001373806,0.0004013804],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6553922,"threshold_uncertainty_score":0.3647228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06362564129860225,"score_gpt":0.365397047101008,"score_spread":0.3017714058024057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}