{"id":"W3093618934","doi":"10.1093/braincomms/fcaa177","title":"Grey matter network trajectories across the Alzheimer’s disease continuum and relation to cognition","year":2020,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Pfizer; Biogen; BioClinica; Alzheimer Nederland; Eisai; Amsterdam Neuroscience; ZonMw; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cognitive decline; Dementia; Cognition; Disease; Grey matter; Psychology; Alzheimer's disease; Cognitive reserve; Mini–Mental State Examination; Neuroscience; Medicine; Cognitive impairment; Pathology; White matter; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005498622,0.0002174552,0.0002317825,0.0006665101,0.0002904794,0.0004882621,0.0002290383,0.0003065267,0.0008654341],"category_scores_gemma":[0.0024389,0.0001245251,0.0002836585,0.00068546,0.0002429837,0.0006935152,0.0005012662,0.0003105116,0.00008921949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004565021,"about_ca_system_score_gemma":0.0002366251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01182961,"about_ca_topic_score_gemma":0.0247223,"domain_scores_codex":[0.9998254,0.00004562736,0.00001035912,0.00006926651,0.00002123803,0.00002816374],"domain_scores_gemma":[0.9992472,0.0002074144,0.0002714075,0.00009139041,0.00009152045,0.00009114661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002684204,0.00002912224,0.9865827,0.00002000464,0.000202151,0.0001091614,0.00036494,0.001989787,0.002024793,0.0004317337,0.0002108366,0.00776638],"study_design_scores_gemma":[0.000002188291,0.00004858504,0.9966705,0.000005086444,0.00002118568,0.00008491438,0.00009550895,0.001883211,0.0001324524,0.0008471298,0.000205665,0.000003490941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981486,0.0002547724,0.0007941606,0.00007618377,0.000003279826,0.000007561956,0.0003784928,0.000006703702,0.0003302771],"genre_scores_gemma":[0.9986278,0.0001162716,0.0006292733,0.00001144253,0.000003380418,0.0000121611,0.0003713654,0.000002617066,0.0002257178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01182961,"threshold_uncertainty_score":0.02352154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06362564129860225,"score_gpt":0.365397047101008,"score_spread":0.3017714058024057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}