{"id":"W3093643846","doi":"10.1002/aur.2418","title":"<scp>CIM6P</scp>/<scp>IGF</scp>‐2 Receptor Ligands Reverse Deficits in Angelman Syndrome Model Mice","year":2020,"lang":"en","type":"article","venue":"Autism Research","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute on Aging; National Institute of Mental Health; Foundation for Angelman Syndrome Therapeutics","keywords":"UBE3A; Angelman syndrome; Insulin-like growth factor 2 receptor; Neuroscience; Neurodevelopmental disorder; Psychology; Ataxia; Receptor; Insulin-like growth factor 1 receptor; Endocrinology; Internal medicine; Medicine; Autism; Growth factor; Chemistry; Developmental psychology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001079586,0.0003202512,0.0003731223,0.0002083874,0.0002090888,0.0001101271,0.0008114829,0.0004403127,0.00002152375],"category_scores_gemma":[0.001947149,0.0003392958,0.000157167,0.0007377717,0.0001799447,0.00001592652,0.0009189899,0.0007272753,0.0003915012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005446145,"about_ca_system_score_gemma":0.000311507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001378162,"about_ca_topic_score_gemma":0.00003641513,"domain_scores_codex":[0.9963495,0.0002072968,0.0004744904,0.001025302,0.000668324,0.001275148],"domain_scores_gemma":[0.9984494,0.000203622,0.00009637413,0.0006244222,0.0001576359,0.0004685672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007245789,0.0001534604,0.005477979,0.0001704311,0.00008007324,0.00009625401,0.001201742,0.0007129101,0.9302859,0.0002534764,0.0601248,0.001435771],"study_design_scores_gemma":[0.005479362,0.003936002,0.07777175,0.0004728821,0.00007386252,0.000572731,0.006685379,0.03437291,0.5370156,0.001350634,0.331584,0.000684868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904531,0.002097134,0.0002724938,0.001010532,0.0001255781,0.0004959133,0.00004124359,0.00003750774,0.005466538],"genre_scores_gemma":[0.9893023,0.001134971,0.001630932,0.0004703627,0.0001238816,0.00007142354,0.00009946964,0.00008618861,0.007080477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3932703,"threshold_uncertainty_score":0.9999059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04950761889439175,"score_gpt":0.3050428915889375,"score_spread":0.2555352726945458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}