{"id":"W3093675505","doi":"10.1016/j.ijrobp.2020.07.2104","title":"Interim Analysis of a Phase II Multi-institution Randomized Placebo-controlled Trial the PREMIUM trial (PREvention of Metabolic Syndrome and Increased weight Using Metformin concurrent to ADT and EBRT for locally advanced adenocarcinoma of the prostate)","year":2020,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; University of Calgary; University of Manitoba; BC Cancer Agency; CancerCare Manitoba","funders":"","keywords":"Medicine; Metformin; Waist; Metabolic syndrome; Placebo; Androgen deprivation therapy; Interim analysis; Internal medicine; Prostate cancer; Lipid profile; Weight loss; Randomized controlled trial; Urology; Endocrinology; Insulin; Body mass index; Cholesterol; Obesity; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006944598,0.002763252,0.007101268,0.0004767099,0.00080567,0.002178976,0.001008356,0.002183384,0.01387287],"category_scores_gemma":[0.007142018,0.0008651534,0.005502736,0.0006435948,0.0009667441,0.001826802,0.0007249926,0.004705049,0.001672944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007489221,"about_ca_system_score_gemma":0.001593481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000664226,"about_ca_topic_score_gemma":0.001427579,"domain_scores_codex":[0.9969636,0.001693072,0.0001835323,0.0004442127,0.0002160878,0.0004995891],"domain_scores_gemma":[0.9961691,0.001495153,0.0008222765,0.0007021531,0.0003152526,0.0004959941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9874632,0.001140898,0.0004782857,0.0003838766,0.003281196,0.00003449272,0.00002089151,0.0005256527,0.0007930577,0.000165594,0.001302739,0.004410118],"study_design_scores_gemma":[0.9526135,0.03495119,0.004161929,0.0000582423,0.004484869,0.00004989731,0.00002397208,0.000785461,0.0005958477,0.0008416931,0.001396683,0.0000366787],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9008718,0.01578402,0.01598699,0.003098584,0.004630987,0.02283887,0.02175875,0.001390988,0.01363919],"genre_scores_gemma":[0.9435945,0.002067188,0.009505743,0.003228881,0.0008305638,0.02122143,0.009843808,0.0002291204,0.009478682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01387287,"threshold_uncertainty_score":0.04640937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04241235593171579,"score_gpt":0.391076250077426,"score_spread":0.3486638941457102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}