{"id":"W3093693971","doi":"10.1101/2020.10.26.355750","title":"Principal component analysis of RNA-seq data unveils a novel prostate cancer-associated gene expression signature","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Principal component analysis; Gene; Prostate cancer; Gene expression; Gene signature; Fusion gene; Gene expression profiling; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007208731,0.0005891251,0.0005488623,0.001243237,0.0003786442,0.001065652,0.0002299167,0.0002662801,0.001475013],"category_scores_gemma":[0.001290557,0.0001423165,0.0007645608,0.001321827,0.0003996348,0.0002236694,0.0004498357,0.0006139454,0.001027653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003213777,"about_ca_system_score_gemma":0.0007642235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001608885,"about_ca_topic_score_gemma":0.002644785,"domain_scores_codex":[0.9993235,0.00009414239,0.00004319156,0.000241504,0.0002011503,0.00009640939],"domain_scores_gemma":[0.9993155,0.0002478103,0.0001022471,0.00006983054,0.0002116164,0.00005309014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00135447,0.0003090192,0.09667427,0.0009734135,0.0005555525,0.000526034,0.0004258462,0.01417399,0.729569,0.002187494,0.009089747,0.1441612],"study_design_scores_gemma":[0.00007848788,0.000820083,0.5060518,0.0001348246,0.0005185079,0.001508555,0.0006332959,0.2982772,0.1557602,0.008247533,0.02773037,0.0002389958],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7765574,0.001319102,0.1905882,0.0005495014,0.00017542,0.0002476025,0.02396682,0.00360774,0.002988163],"genre_scores_gemma":[0.8807746,0.0005545322,0.08790777,0.0002835998,0.00009993396,0.000266,0.02766365,0.0005367115,0.001913177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608885,"threshold_uncertainty_score":0.004934371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02726471115084284,"score_gpt":0.2753715948316875,"score_spread":0.2481068836808447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}