{"id":"W3093697902","doi":"10.1016/j.isci.2020.101726","title":"Severe Impairment of TNF Post-transcriptional Regulation Leads to Embryonic Death","year":2020,"lang":"en","type":"article","venue":"iScience","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stanford Institute for Research in the Social Sciences; Australian Government; Campbell Family Institute for Breast Cancer Research; National Health and Medical Research Council; Arthritis Australia; Leukemia and Lymphoma Society","keywords":"Post-transcriptional regulation; Transcriptional regulation; Tumor necrosis factor alpha; Downregulation and upregulation; Messenger RNA; Untranslated region; Cell biology; Biology; Translational efficiency; Inflammation; Embryonic stem cell; Regulation of gene expression; Cytokine; Translational regulation; In vivo; Gene expression; Translation (biology); Immunology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001923546,0.0004196205,0.00042895,0.000354939,0.0001561799,0.000293235,0.000217659,0.0003665873,0.001806362],"category_scores_gemma":[0.0002340925,0.0002039957,0.0002599848,0.0001810184,0.0003418768,0.0001781376,0.0003005516,0.0008114382,0.0006546726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002570322,"about_ca_system_score_gemma":0.0001812486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003134526,"about_ca_topic_score_gemma":0.0003880363,"domain_scores_codex":[0.999746,0.00005320406,0.00004009708,0.000050101,0.00006915573,0.00004155218],"domain_scores_gemma":[0.9995054,0.0001396962,0.0001299264,0.00007859839,0.00002266831,0.0001238033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001850652,0.00001961939,0.0002408486,0.00002528479,0.000007659651,0.0002659881,0.00001415353,0.00008515278,0.9975833,0.0002248746,0.00004515186,0.001303007],"study_design_scores_gemma":[0.00003286947,0.0005633653,0.008548293,0.00001443021,0.00002618659,0.001842758,0.00004090852,0.001097442,0.9842631,0.0002677444,0.003292786,0.00001016464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807284,0.003175653,0.01051601,0.0001370431,0.00008746584,0.0000481985,0.001161524,0.0003628361,0.003782844],"genre_scores_gemma":[0.9897748,0.001445993,0.003292251,0.00008693942,0.00001276385,0.0000455171,0.0009723396,0.00005681294,0.00431252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001806362,"threshold_uncertainty_score":0.006042838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01798715230097526,"score_gpt":0.2764079740013596,"score_spread":0.2584208217003843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}