{"id":"W3093738953","doi":"10.1039/d0md00303d","title":"Identification of P218 as a potent inhibitor of <i>Mycobacterium ulcerans</i> DHFR","year":2020,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Canada; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Boehringer Ingelheim; Merck KGaA; AbbVie; Innovative Medicines Initiative; Wellcome; National Institute of Allergy and Infectious Diseases; Bayer; Takeda Pharmaceuticals U.S.A.; Pfizer","keywords":"Mycobacterium ulcerans; Virology; Biology; Buruli ulcer; Microbiology; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002492582,0.0004627257,0.00033656,0.0002883438,0.0003043845,0.0003564111,0.0004212283,0.0003736661,0.003116562],"category_scores_gemma":[0.0002404575,0.0001229218,0.0002668628,0.0002241168,0.00017087,0.0001875349,0.0002486384,0.00061438,0.0009812911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821303,"about_ca_system_score_gemma":0.0003181618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009933667,"about_ca_topic_score_gemma":0.002106244,"domain_scores_codex":[0.9999157,0.00001769577,0.00000425349,0.00001229372,0.00002215795,0.00002787564],"domain_scores_gemma":[0.9999503,0.000008251894,0.000008125285,0.000005153213,0.00001258471,0.00001552633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001103273,0.00054694,0.0007880594,0.0003424021,0.00004691506,0.0009324085,0.00008009945,0.001156394,0.9472569,0.0008230199,0.003348607,0.04357507],"study_design_scores_gemma":[0.000898846,0.009399527,0.005824124,0.00007013206,0.0001219536,0.003152933,0.00006118311,0.004075357,0.918795,0.0005371407,0.05702258,0.00004123142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9386831,0.01701225,0.01106189,0.001726389,0.0004312312,0.0006961388,0.001731273,0.0004444,0.0282133],"genre_scores_gemma":[0.9723883,0.008896632,0.005318893,0.0004321994,0.0001352925,0.0001527315,0.002367578,0.00004047506,0.01026792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003116562,"threshold_uncertainty_score":0.01042587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528075898154541,"score_gpt":0.2739815784650237,"score_spread":0.2587008194834783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}