{"id":"W3093762650","doi":"10.14309/01.ajg.0000705572.04908.5f","title":"S0881 Therapeutic Drug Monitoring Dosing Regimen With Adalimumab in Patients With Moderately to Severely Active Ulcerative Colitis: Results From the SERENE-UC Maintenance Study","year":2020,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Ulcerative colitis; Dosing; Regimen; Therapeutic drug monitoring; Maintenance therapy; Adalimumab; Internal medicine; Randomized controlled trial; Maintenance dose; Pharmacokinetics; Surgery; Chemotherapy; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002580456,0.0005238811,0.001633314,0.0002739175,0.0002770205,0.0007872994,0.0004133794,0.0009321429,0.002152149],"category_scores_gemma":[0.001867147,0.0001926826,0.001954569,0.0004460482,0.0003211033,0.0007556587,0.0003102432,0.001686048,0.0005215259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002964527,"about_ca_system_score_gemma":0.000473293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003384189,"about_ca_topic_score_gemma":0.0006608504,"domain_scores_codex":[0.9990848,0.0004952376,0.000111328,0.0001030605,0.0001318508,0.00007371933],"domain_scores_gemma":[0.9986202,0.0003259947,0.0004281229,0.000183979,0.0001266984,0.0003150833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7492903,0.02049209,0.04314983,0.001031567,0.003337391,0.0001584259,0.00024175,0.0007151158,0.01054948,0.0001220554,0.002629516,0.1682824],"study_design_scores_gemma":[0.1903724,0.6418324,0.1564691,0.0002093042,0.002313388,0.0003878076,0.0001090439,0.0009570945,0.0015128,0.0001413303,0.005636284,0.00005898018],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905366,0.005527404,0.0002603623,0.000336802,0.00007847784,0.0004763093,0.0008682887,0.00003512733,0.001880554],"genre_scores_gemma":[0.9934959,0.001751789,0.0007416586,0.0007264849,0.0001965042,0.000337355,0.0017979,0.000009586084,0.0009426965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002580456,"threshold_uncertainty_score":0.0136469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008428121928385086,"score_gpt":0.2256103163301864,"score_spread":0.2171821944018013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}