{"id":"W3093807572","doi":"10.3390/molecules25204825","title":"Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Plant Toxicity and Pharmacological Properties","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Division of Chemistry; Monique Weill-Caulier Trust; National Institutes of Health; Secretaría de Educación Superior, Ciencia, Tecnología e Innovación; National Science Foundation","keywords":"Morpholine; Chemistry; Adduct; Gene isoform; Proline; Stereochemistry; Peripheral blood mononuclear cell; Sesquiterpene lactone; Cytotoxic T cell; Biochemistry; Amino acid; Molecular biology; Sesquiterpene; Gene; Biology; In vitro; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005243934,0.00008840922,0.0001452249,0.0000115036,0.00003361737,0.000003839814,0.0001662945,0.00007295743,0.00001240717],"category_scores_gemma":[0.00009643799,0.00005837891,0.00006914198,0.00005225828,0.0002137712,0.000002380864,0.000147917,0.00006412038,4.500679e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001494869,"about_ca_system_score_gemma":0.00002097911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001164728,"about_ca_topic_score_gemma":0.000002706649,"domain_scores_codex":[0.9994772,0.00008146742,0.0001098192,0.0001574321,0.0000772562,0.00009679418],"domain_scores_gemma":[0.9997291,0.00002098383,0.00007619725,0.0001062358,0.00002428562,0.00004318316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001027639,0.00003604356,0.001436481,0.00006519592,0.00004333636,0.000001110921,0.00002445867,0.00004737524,0.9974078,0.00002891266,0.0002446485,0.0005618946],"study_design_scores_gemma":[0.0001399748,0.0001033515,0.0103197,0.00001194868,0.00002749006,0.000003646713,0.000009738941,0.0001373649,0.9883113,0.00002057282,0.000844031,0.0000709185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998013,0.0008619798,0.0001142172,0.0004070023,0.00001918374,0.00008430239,0.00006952544,0.000005063773,0.0004256904],"genre_scores_gemma":[0.999172,0.0003647856,0.00008938587,0.0003249389,0.0000251987,0.000003813248,0.000003682223,0.000005372066,0.00001077716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009096514,"threshold_uncertainty_score":0.2380623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195833000581984,"score_gpt":0.2193111052587354,"score_spread":0.199727805200537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}