{"id":"W3093807572","doi":"10.3390/molecules25204825","title":"Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Plant Toxicity and Pharmacological Properties","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Division of Chemistry; Monique Weill-Caulier Trust; National Institutes of Health; Secretaría de Educación Superior, Ciencia, Tecnología e Innovación; National Science Foundation","keywords":"Morpholine; Chemistry; Adduct; Gene isoform; Proline; Stereochemistry; Peripheral blood mononuclear cell; Sesquiterpene lactone; Cytotoxic T cell; Biochemistry; Amino acid; Molecular biology; Sesquiterpene; Gene; Biology; In vitro; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006346225,0.0002086524,0.000100519,0.0001619258,0.0001156791,0.0001012584,0.0001446133,0.0001092652,0.0007852404],"category_scores_gemma":[0.00007936983,0.00007789665,0.00007931521,0.0001887159,0.00009714894,0.0001239226,0.0001045585,0.0002273926,0.0001980346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001581567,"about_ca_system_score_gemma":0.0001823355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006685832,"about_ca_topic_score_gemma":0.001117734,"domain_scores_codex":[0.9999723,0.000004766807,0.000002257287,0.000005809018,0.000008313157,0.000006480199],"domain_scores_gemma":[0.9999539,0.000004232764,0.00001351095,0.000007299923,0.000009005945,0.00001206699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009817242,0.00001892353,0.0002020422,0.00005649942,0.00000406472,0.0001218005,0.00003832469,0.0004348391,0.9950649,0.0002096989,0.00005399486,0.003696622],"study_design_scores_gemma":[0.00001700326,0.0001748433,0.001357613,0.000005927828,0.000008562243,0.0001351387,0.00002560273,0.0005282695,0.9905518,0.0000488836,0.00714051,0.000005810302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907116,0.001391271,0.004319521,0.00007974343,0.00001480213,0.00004268924,0.0005042141,0.00005557165,0.002880675],"genre_scores_gemma":[0.9892225,0.001627786,0.005595891,0.00002050311,0.000006154807,0.00001949619,0.0006244581,0.00002104132,0.002862193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007852404,"threshold_uncertainty_score":0.002626836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195833000581984,"score_gpt":0.2193111052587354,"score_spread":0.199727805200537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}