{"id":"W3093837531","doi":"10.1016/j.ijrobp.2020.07.2107","title":"A Phase 2 Study of Neo-adjuvant Metformin and Temozolomide followed by Hypofractionated Accelerated RadioTherapy (HART) with Concomitant and Adjuvant Metformin and Temozolomide (TMZ) in Patients with Glioblastoma","year":2020,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University Health Centre; McGill University","funders":"","keywords":"Medicine; Temozolomide; Concomitant; Metformin; Adjuvant; Radiation therapy; Surgery; Internal medicine; Urology; Oncology; Nuclear medicine; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001302805,0.001729612,0.00331482,0.0006073071,0.0004948697,0.001008158,0.0009842705,0.00111824,0.003181189],"category_scores_gemma":[0.000839954,0.001022035,0.001824624,0.0006641412,0.001284563,0.001399327,0.0004639679,0.003415063,0.0006411243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001137206,"about_ca_system_score_gemma":0.002477729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002092486,"about_ca_topic_score_gemma":0.0055277,"domain_scores_codex":[0.9995906,0.0001515406,0.00002010841,0.0001044666,0.000029305,0.0001040322],"domain_scores_gemma":[0.9993989,0.00007382321,0.00007874727,0.00006925684,0.00003525318,0.0003439412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.89467,0.06407652,0.002435481,0.0002574624,0.0007386138,0.00007626318,0.0001599136,0.0009178567,0.01213407,0.0001336316,0.0006615095,0.02373886],"study_design_scores_gemma":[0.4853311,0.504481,0.006297685,0.00001669963,0.0005878054,0.00008601657,0.00006936157,0.0005374834,0.001379748,0.000140647,0.001039024,0.000033295],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969764,0.0008014204,0.0002015031,0.000190899,0.0001341377,0.0009166318,0.0002618184,0.00002591048,0.0004912875],"genre_scores_gemma":[0.9922603,0.001513823,0.001242164,0.0004505269,0.0002144282,0.001554084,0.0008871672,0.00002410472,0.001853479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00331482,"threshold_uncertainty_score":0.01064211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01563818273854987,"score_gpt":0.3081586092482873,"score_spread":0.2925204265097374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}