{"id":"W3093864427","doi":"10.1016/j.jaci.2020.10.015","title":"Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: A randomized, double-blind, placebo-controlled phase 3 trial","year":2020,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Allergy Research Corporation","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institutes of Health; BioCryst; Ionis Pharmaceuticals; Regeneron Pharmaceuticals; Sanofi; AstraZeneca; Aimmune Therapeutics; CSL Behring; Harvard Catalyst; GlaxoSmithKline; Genentech","keywords":"Medicine; Hereditary angioedema; Placebo; Tolerability; Adverse effect; Nausea; Vomiting; Randomized controlled trial; Abdominal pain; Internal medicine; Clinical endpoint; Angioedema; Diarrhea; Anesthesia; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002481334,0.0002115979,0.002057623,0.0000813856,0.0001113359,0.00001956752,0.0001951609,0.0003135474,0.0001905531],"category_scores_gemma":[0.001690915,0.0001258555,0.001609845,0.0001195806,0.000534233,0.0001586557,0.00004762487,0.0004253453,0.000002732302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001527044,"about_ca_system_score_gemma":0.0003088793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002110654,"about_ca_topic_score_gemma":0.00002869332,"domain_scores_codex":[0.9963812,0.0004783206,0.002430798,0.0002223233,0.000240155,0.0002472425],"domain_scores_gemma":[0.994064,0.003712759,0.001500559,0.0001778725,0.0003716854,0.0001731114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9735718,0.0009656114,0.00005961443,0.000023141,0.008580278,0.00002437324,0.000316092,0.00002529438,0.0001612429,0.0004791275,0.001870554,0.01392282],"study_design_scores_gemma":[0.9781045,0.01202674,0.0002416736,0.0001118072,0.001997267,0.0001105287,0.0003524081,0.001445667,0.0001568745,0.0006077537,0.004729012,0.0001157227],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602542,0.0162864,0.00364871,0.01550914,0.001517839,0.002663223,0.000007225725,0.00001690479,0.00009637493],"genre_scores_gemma":[0.9894775,0.006086682,0.0008156269,0.0008885551,0.002019647,0.00007669644,0.00002055022,0.00002675766,0.0005880254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02922328,"threshold_uncertainty_score":0.5132239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09577189653942489,"score_gpt":0.4001914682474612,"score_spread":0.3044195717080362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}