{"id":"W3093870157","doi":"10.1101/2020.10.22.343673","title":"Potential Achilles heels of SARS-CoV-2 are best displayed by the base order-dependent component of RNA folding energy","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"NIH Clinical Center; Fudan University; Queen's University; Jiangsu University","keywords":"RNA; Folding (DSP implementation); Nucleic acid; Base pair; Biology; Component (thermodynamics); Nucleic acid structure; Virology; Computational biology; Genetics; DNA; Physics; Gene; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000241461,0.0002987088,0.0002699358,0.0003394498,0.000195649,0.0004357361,0.0001161369,0.0003160663,0.003885159],"category_scores_gemma":[0.0002224558,0.0001112306,0.0001729231,0.0001703707,0.0002703941,0.0002684516,0.0001700131,0.0003805145,0.0006444335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611077,"about_ca_system_score_gemma":0.0001282373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002803082,"about_ca_topic_score_gemma":0.0004535883,"domain_scores_codex":[0.9998906,0.00002047993,0.000007267655,0.00001841722,0.00003304822,0.00003023512],"domain_scores_gemma":[0.9998566,0.00002870045,0.00004031349,0.00001463783,0.00001851917,0.00004124191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005629358,0.00004370269,0.007399173,0.00004419841,0.00001670733,0.0002340663,0.00003551249,0.0002069655,0.9871132,0.00038785,0.0001195086,0.003836208],"study_design_scores_gemma":[0.0000460333,0.001424633,0.123793,0.0000230597,0.00004374373,0.002366324,0.0004055699,0.003067566,0.8624318,0.002014054,0.004365446,0.00001866308],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951769,0.0007422658,0.001262881,0.0001653451,0.0000139062,0.0000071027,0.000168098,0.00003902382,0.002424472],"genre_scores_gemma":[0.997169,0.0001671422,0.0009343069,0.00005962686,0.000009445916,0.000003241901,0.0002934262,0.000008357149,0.001355625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003885159,"threshold_uncertainty_score":0.01299715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03574019401169189,"score_gpt":0.2862605192855766,"score_spread":0.2505203252738847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}