{"id":"W3093945819","doi":"10.14309/01.ajg.0000706552.82327.43","title":"S1126 Safety and Efficacy of Switching to Tenofovir Alafenamide (TAF) in Virally Suppressed Chronic Hepatitis B (CHB) Patients With Hepatic Impairment: Week 48 Results From a Phase 2 Open Label Study","year":2020,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Toronto Liver Centre","funders":"","keywords":"Medicine; Tenofovir alafenamide; Entecavir; Internal medicine; HBeAg; Gastroenterology; Renal function; Creatinine; Hepatitis B; Adverse effect; Hepatitis B virus; HBsAg; Viral load; Lamivudine; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001086575,0.0006147265,0.001417496,0.0002220703,0.0002652025,0.0007448529,0.0003473894,0.001184776,0.005056377],"category_scores_gemma":[0.001097815,0.0003203728,0.001061383,0.0002593308,0.0004060779,0.0006017628,0.0001984366,0.001695859,0.001004239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003132982,"about_ca_system_score_gemma":0.000493697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002696601,"about_ca_topic_score_gemma":0.0005671827,"domain_scores_codex":[0.9994745,0.0002740878,0.00004995491,0.00007368762,0.00006699174,0.00006084103],"domain_scores_gemma":[0.9992546,0.0001647897,0.0002556933,0.00006212244,0.00007884989,0.0001838738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7488235,0.03885994,0.01715583,0.00111238,0.001640695,0.0002699285,0.0002207725,0.001510271,0.05437333,0.00009886485,0.003189457,0.1327449],"study_design_scores_gemma":[0.3913197,0.5571694,0.03933199,0.00009715927,0.0006328998,0.0005011818,0.00006558288,0.001589734,0.006032207,0.0001388955,0.003068974,0.00005233393],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964142,0.001066566,0.0002245199,0.0001724839,0.00005646628,0.0004640322,0.0006580254,0.00005704761,0.0008866474],"genre_scores_gemma":[0.9955936,0.0004926609,0.0005036423,0.0003335573,0.00008546213,0.0005649182,0.001097295,0.00001328351,0.001315623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005056377,"threshold_uncertainty_score":0.01691526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01778623623619407,"score_gpt":0.2913037373048694,"score_spread":0.2735175010686753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}