{"id":"W3093946734","doi":"10.1016/j.neo.2020.10.006","title":"Tumor cell endogenous HIF-1α activity induces aberrant angiogenesis and interacts with TRAF6 pathway required for colorectal cancer development","year":2020,"lang":"en","type":"article","venue":"Neoplasia","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Krembil Foundation","funders":"Natural Sciences and Engineering Research Council of Canada; Universität Zürich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Angiogenesis; Carcinogenesis; Cancer research; Colorectal cancer; Hypoxia (environmental); Neovascularization; Inflammation; Adenocarcinoma; HIF1A; Biology; Pathology; Medicine; Immunology; Chemistry; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008171371,0.0002110475,0.0002125835,0.0000358246,0.0001298319,0.0000380049,0.0001465452,0.0000844321,0.0000233579],"category_scores_gemma":[0.00006680925,0.0001840138,0.00005148597,0.0001118814,0.00006355303,0.000009571268,0.0001067288,0.00008868759,0.000004516621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004813034,"about_ca_system_score_gemma":0.0003856121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006406138,"about_ca_topic_score_gemma":0.0004967791,"domain_scores_codex":[0.9987872,0.00005200617,0.0001339961,0.0005130412,0.0001589974,0.000354725],"domain_scores_gemma":[0.9994496,0.00004916625,0.00007625455,0.000114401,0.0001036019,0.0002070511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001220076,0.00006475779,0.002957345,0.00008769147,0.00009980975,0.00002696763,0.0009164313,0.000004751822,0.9737441,0.000001572123,0.00009647154,0.02078003],"study_design_scores_gemma":[0.001068904,0.0008798747,0.01777089,0.00001552809,0.00001838852,0.00003093329,0.0001223788,0.00002706143,0.9735633,0.000001258535,0.006264087,0.0002373785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978477,0.0006443785,0.0002200353,0.0002521522,0.00005521798,0.0006456055,0.00007764838,0.00001930271,0.0002379837],"genre_scores_gemma":[0.9988247,0.00003180501,0.0005299545,0.00009996704,0.0001316254,0.0002454957,0.00003951887,0.0000387627,0.00005821017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02054265,"threshold_uncertainty_score":0.7503864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04114761277859637,"score_gpt":0.2641915564841222,"score_spread":0.2230439437055258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}