{"id":"W3093948793","doi":"10.24875/aidsrev.20000005","title":"Drug-drug Interactions in Patients with HIV and Cancer in Sub-Saharan Africa","year":2021,"lang":"en","type":"review","venue":"Aids Reviews","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Cancer Institute; National Institutes of Health","keywords":"Drug; Dolutegravir; Medicine; Polypharmacy; Pharmacology; DrugBank; Cancer; Concomitant; Drug interaction; ANTIRETROVIRAL AGENTS; Drug repositioning; Population; Human immunodeficiency virus (HIV); Pharmacokinetics; Antiretroviral therapy; Internal medicine; Family medicine; Viral load; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003220758,0.0005265742,0.003096502,0.0004459565,0.00003616637,0.00002545363,0.00009759923,0.0000591062,0.0003263884],"category_scores_gemma":[0.00006886455,0.0003296487,0.0002575319,0.0009756155,0.00003654257,0.0001071308,0.00007469445,0.0005142877,0.0001898018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004794455,"about_ca_system_score_gemma":0.0003468355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004566815,"about_ca_topic_score_gemma":0.0007253856,"domain_scores_codex":[0.9975014,0.000330643,0.001025216,0.0005922577,0.0002257033,0.0003247987],"domain_scores_gemma":[0.9989746,0.0001108718,0.0003115423,0.0004037014,0.00005758935,0.0001417286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009118967,0.000298265,0.01418066,0.008089737,0.0001531393,0.0000610801,0.0002537087,3.013305e-8,1.614349e-8,0.00000304082,0.02258675,0.9543645],"study_design_scores_gemma":[0.001025019,0.00001820486,0.0007860367,0.0969548,0.0008755724,0.00000826354,0.000008804524,3.055571e-7,2.572548e-7,8.225282e-7,0.9000464,0.0002755322],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000152928,0.9955417,0.00000102954,0.0001846364,0.0001218719,0.002803232,0.00004597896,0.00001436927,0.001134274],"genre_scores_gemma":[0.00001303725,0.9812977,0.0004915775,0.00004566864,0.00005078121,0.001386997,0.000515796,0.00005399133,0.01614449],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9540889,"threshold_uncertainty_score":0.9999155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03691685907530889,"score_gpt":0.3299666021540348,"score_spread":0.2930497430787259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}