{"id":"W3093967508","doi":"10.1093/hmg/ddaa226","title":"Interregulation between fragile X mental retardation protein and methyl CpG binding protein 2 in the mouse posterior cerebral cortex","year":2020,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"MECP2; FMR1; Fragile X syndrome; Rett syndrome; Neurodevelopmental disorder; Biology; Gene knockdown; Gene silencing; Cerebral cortex; Knockout mouse; Neuroscience; Autism; Small hairpin RNA; RNA-binding protein; Cell biology; Phenotype; Messenger RNA; Genetics; Gene; Medicine; Fragile x; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001368947,0.0002116284,0.0001460366,0.00005134702,0.000116403,0.00007816475,0.0002437518,0.0001162722,0.00001603157],"category_scores_gemma":[0.00002340777,0.0002000343,0.00005588167,0.0001180674,0.00007847448,0.000005457317,0.0002036548,0.000135508,0.000005528448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001288668,"about_ca_system_score_gemma":0.00002600231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007710194,"about_ca_topic_score_gemma":0.00002362491,"domain_scores_codex":[0.9986752,0.0001247977,0.0002972528,0.000448808,0.0002191871,0.0002347545],"domain_scores_gemma":[0.9995494,0.000002579482,0.0001002194,0.0002369967,0.00002896852,0.00008187586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002227176,0.0000235786,0.002714767,0.00002260784,0.00002239407,0.000003814386,0.0004310204,0.00001022185,0.995515,0.0000325062,0.00006755031,0.001134192],"study_design_scores_gemma":[0.0007959377,0.0005636251,0.07125837,0.0000181046,0.00002044815,0.000004660516,0.0003290629,0.0001301996,0.9250876,0.0001120368,0.001370037,0.0003099382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997792,0.0001786427,0.0003512353,0.0005033735,0.00001552352,0.001019239,0.00002776917,0.00001066076,0.0001015389],"genre_scores_gemma":[0.9978765,0.00001155912,0.0009291814,0.0003977657,0.00003143504,0.0000840876,0.0005575924,0.00003919185,0.00007269884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07042749,"threshold_uncertainty_score":0.815716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966629561752241,"score_gpt":0.2510831613031529,"score_spread":0.2314168656856305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}