{"id":"W3093970143","doi":"10.1016/j.carbpol.2020.117261","title":"The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V","year":2020,"lang":"en","type":"article","venue":"Carbohydrate Polymers","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Narodowe Centrum Nauki; Institut National de la Santé et de la Recherche Médicale; Université François-Rabelais; Centre National de la Recherche Scientifique; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation","keywords":"Cathepsin; Heparan sulfate; Mucopolysaccharidosis; Extracellular matrix; Chemistry; Glycosaminoglycan; Cell biology; Internal medicine; Endocrinology; Medicine; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001853793,0.0005254854,0.0003685784,0.0007692307,0.0002815035,0.0003651565,0.0001698883,0.0003985626,0.001697224],"category_scores_gemma":[0.00101803,0.0002423028,0.0002000665,0.0004145163,0.0003114966,0.0002096163,0.0002012508,0.0003496908,0.0002159346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686827,"about_ca_system_score_gemma":0.000139083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007078093,"about_ca_topic_score_gemma":0.0005488048,"domain_scores_codex":[0.9998252,0.00004136213,0.00003844462,0.00003531796,0.00003490329,0.00002478614],"domain_scores_gemma":[0.9996479,0.0001072291,0.0001091773,0.00002984611,0.00003465682,0.00007120747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004710802,0.0001354827,0.307538,0.0001734348,0.0003190754,0.01532843,0.0006102894,0.0005354882,0.6495649,0.0005674763,0.0004959765,0.02002059],"study_design_scores_gemma":[0.0001558861,0.0008310228,0.7539082,0.0000345967,0.0003127471,0.0541541,0.0003949363,0.00204539,0.1854926,0.0006552757,0.00198888,0.00002645754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988679,0.0002724175,0.0003710217,0.00004713801,0.000006701691,0.000002250942,0.00007884124,0.0000204888,0.0003333085],"genre_scores_gemma":[0.9995957,0.00004742455,0.0001559591,0.00001163099,0.000005076267,0.000001207029,0.00005365109,0.000004887515,0.0001243606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001697224,"threshold_uncertainty_score":0.00567776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463004653776654,"score_gpt":0.2398715096483544,"score_spread":0.2252414631105878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}