{"id":"W3093982502","doi":"10.1158/1535-7163.mct-20-0333","title":"TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université du Québec à Montréal; Centre Hospitalier Universitaire Sainte-Justine; Hôpital Maisonneuve-Rosemont; Université de Montréal; McGill University","funders":"Merck Sharp and Dohme; McGill University Health Centre; Meso Scale Diagnostics; Merck","keywords":"Apoptosis; Oxidative stress; Programmed cell death; Chemistry; Protein kinase B; Cancer cell; Cancer research; Cell culture; Biology; Biochemistry; Cancer; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005466007,0.0002992381,0.0001383618,0.0002836975,0.0001218562,0.0001486214,0.0001569886,0.0002086329,0.0008558652],"category_scores_gemma":[0.000036389,0.00006866066,0.0001204184,0.000172387,0.0001132357,0.0001513684,0.0001174353,0.0003067293,0.0002251944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001098621,"about_ca_system_score_gemma":0.0001037394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001414703,"about_ca_topic_score_gemma":0.0003086519,"domain_scores_codex":[0.9999774,0.000003068659,0.000001747394,0.000004943454,0.000006820562,0.000006085304],"domain_scores_gemma":[0.999974,0.000002232826,0.000008698438,0.00000306229,0.000004614242,0.000007399573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001129139,0.00007430869,0.0001180696,0.00008352264,0.000005342098,0.0001203371,0.000008617603,0.00008292366,0.9923519,0.0001726859,0.0001398118,0.006729602],"study_design_scores_gemma":[0.00003862531,0.001307938,0.001493042,0.000005928593,0.00002894414,0.0009788675,0.000005761878,0.0003229222,0.9883913,0.00004095226,0.007380949,0.000004730542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741247,0.008683118,0.007851253,0.0002158036,0.00008957929,0.0001219902,0.0005518381,0.0002436672,0.008118006],"genre_scores_gemma":[0.9883986,0.003496202,0.003949224,0.00009281973,0.00003063148,0.00003905277,0.0005154605,0.00001380366,0.003464177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008558652,"threshold_uncertainty_score":0.002863169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04083985853174139,"score_gpt":0.2910652015357341,"score_spread":0.2502253430039927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}