{"id":"W3093982502","doi":"10.1158/1535-7163.mct-20-0333","title":"TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity","year":2020,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université du Québec à Montréal; Centre Hospitalier Universitaire Sainte-Justine; Hôpital Maisonneuve-Rosemont; Université de Montréal; McGill University","funders":"Merck Sharp and Dohme; McGill University Health Centre; Meso Scale Diagnostics; Merck","keywords":"Apoptosis; Oxidative stress; Programmed cell death; Chemistry; Protein kinase B; Cancer cell; Cancer research; Cell culture; Biology; Biochemistry; Cancer; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008289628,0.0003475643,0.000297653,0.00002869554,0.0001178518,0.00005372334,0.0003153271,0.0001659567,0.00001548188],"category_scores_gemma":[0.00003082374,0.0003590684,0.0001694548,0.0001823156,0.0001373452,0.000008267218,0.0001937918,0.0002640891,0.000008684027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006883157,"about_ca_system_score_gemma":0.0001993144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003289839,"about_ca_topic_score_gemma":0.00001461386,"domain_scores_codex":[0.9982597,0.00007220194,0.0002388391,0.000709383,0.000230668,0.0004892594],"domain_scores_gemma":[0.9991385,0.000006321884,0.0001761716,0.0003276148,0.0001715871,0.000179822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002453693,0.0001455687,0.001016264,0.00004753983,0.0002822339,0.0000156449,0.000249628,0.0001383325,0.9937987,0.0000524117,0.0001614881,0.00384682],"study_design_scores_gemma":[0.001112498,0.0002828276,0.000811153,0.00002193136,0.00008155227,0.000009282259,0.00006489836,0.0008777897,0.9839749,0.00005018357,0.01226425,0.0004487787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475808,0.001995257,0.04774421,0.001275727,0.000189272,0.0004828817,0.0001235427,0.00004169594,0.0005666538],"genre_scores_gemma":[0.9928172,0.0002520638,0.002043509,0.004217991,0.0003812391,0.00008512483,0.00005127445,0.00007458142,0.0000770363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0457007,"threshold_uncertainty_score":0.9998862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04083985853174139,"score_gpt":0.2910652015357341,"score_spread":0.2502253430039927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}