{"id":"W3094086985","doi":"10.1016/j.celrep.2020.108286","title":"Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; SickKids Foundation; Hospital for Sick Children","funders":"National Cancer Institute; Cancer Center, University of Colorado; National Institutes of Health; Morgan Adams Foundation; U.S. Department of Defense","keywords":"BMI1; Epigenomics; Senescence; Cancer research; Biology; Chromatin; Phenotype; RNA interference; Histone; Cell biology; Stem cell; Genetics; Gene expression; Gene; DNA methylation; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000801401,0.0001658094,0.0002647041,0.0001740804,0.00009983745,0.0001367656,0.0001322507,0.0001419591,0.0009472836],"category_scores_gemma":[0.000083795,0.00006404229,0.0001554262,0.0001171524,0.0001544788,0.0001033243,0.0001378071,0.0004577514,0.0002003956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001255231,"about_ca_system_score_gemma":0.0001243478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000316255,"about_ca_topic_score_gemma":0.0004181158,"domain_scores_codex":[0.9999481,0.000005846475,0.000003690569,0.00001021916,0.00001311218,0.00001899573],"domain_scores_gemma":[0.9999574,0.00000482719,0.000008115214,0.000005704051,0.00000374561,0.000020164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003981534,0.00009194624,0.0004889941,0.00003021059,0.000006785211,0.0001358375,0.00001420791,0.00005869264,0.9929102,0.00009389501,0.00009184966,0.005679211],"study_design_scores_gemma":[0.00009139913,0.006108034,0.01847758,0.000007655398,0.00004373638,0.002581618,0.00003993088,0.001146072,0.9663503,0.0001251772,0.005021373,0.000007168997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972826,0.0007714648,0.0006699618,0.00006443822,0.00001916874,0.00002189692,0.0001306581,0.00007432464,0.0009655273],"genre_scores_gemma":[0.9982852,0.0003644808,0.000420135,0.00003053932,0.000004550447,0.00001754534,0.0001911085,0.000007427986,0.0006790581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009472836,"threshold_uncertainty_score":0.003169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02023608117901864,"score_gpt":0.2607806856196469,"score_spread":0.2405446044406283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}