{"id":"W3094086985","doi":"10.1016/j.celrep.2020.108286","title":"Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; SickKids Foundation; Hospital for Sick Children","funders":"National Cancer Institute; Cancer Center, University of Colorado; National Institutes of Health; Morgan Adams Foundation; U.S. Department of Defense","keywords":"BMI1; Epigenomics; Senescence; Cancer research; Biology; Chromatin; Phenotype; RNA interference; Histone; Cell biology; Stem cell; Genetics; Gene expression; Gene; DNA methylation; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002527901,0.0001362915,0.0001361844,0.00001836906,0.00004084917,0.00002065801,0.00004927202,0.000162175,0.00003080065],"category_scores_gemma":[0.00008212961,0.0001349879,0.00006016884,0.0001321605,0.00002958328,0.000004282205,0.00005491753,0.0001198913,0.000004394186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001854962,"about_ca_system_score_gemma":0.00007026586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003714636,"about_ca_topic_score_gemma":0.00001058768,"domain_scores_codex":[0.9987417,0.00007344245,0.0003594544,0.0004950459,0.0001477388,0.0001825582],"domain_scores_gemma":[0.9993712,0.000008827913,0.0001496092,0.0003099645,0.00005877338,0.0001016364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001921534,0.00006464658,0.01826801,0.00002200902,0.000004265461,0.00002370971,0.0001478312,0.00001793149,0.9795732,0.000001213068,0.0001109709,0.001747017],"study_design_scores_gemma":[0.0001825391,0.0001513638,0.004798877,0.000006772713,0.000006851824,0.000004010236,0.00002962103,0.00009166722,0.9883161,0.0002676734,0.005982175,0.0001623476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956614,0.001184539,0.001474225,0.0004206394,0.00009065613,0.0002263199,0.000005533428,0.00001206671,0.0009246634],"genre_scores_gemma":[0.9988543,0.0001528499,0.00007177291,0.000654349,0.00008180798,0.0000165327,0.00008910462,0.00001711933,0.00006220643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01346914,"threshold_uncertainty_score":0.5504645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02023608117901864,"score_gpt":0.2607806856196469,"score_spread":0.2405446044406283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}