{"id":"W3094100911","doi":"10.1016/j.ijrobp.2020.07.953","title":"NRG Oncology/RTOG 1119: PHASE II Randomized Study of Whole Brain Radiotherapy/Stereotactic Radiosurgery with Concurrent Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer — A Collaborative Study of NRG and KROG (NCT01622868)","year":2020,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Lapatinib; Radiosurgery; Breast cancer; Radiation therapy; Oncology; Clinical endpoint; Internal medicine; Pertuzumab; Brain metastasis; Metastatic breast cancer; Cancer; Randomized controlled trial; Trastuzumab; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009008113,0.0003908374,0.002168423,0.0002507389,0.00007015808,0.0000191748,0.0002078852,0.0001235363,0.00007870597],"category_scores_gemma":[0.0003603518,0.0002676908,0.0001619139,0.000445934,0.0003893658,0.0002811389,0.00006431239,0.0004501723,5.215359e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005886963,"about_ca_system_score_gemma":0.0009474014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004058242,"about_ca_topic_score_gemma":0.0001813361,"domain_scores_codex":[0.9952665,0.002101137,0.001402635,0.0004431829,0.0005547723,0.0002317601],"domain_scores_gemma":[0.9929957,0.002514625,0.002753085,0.0001646198,0.001358588,0.0002134093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1759456,0.03323846,0.6810534,0.00002308855,0.01315111,0.0002512378,0.02489688,0.0006840882,0.0005463471,0.0000930323,0.0004908999,0.06962582],"study_design_scores_gemma":[0.7389147,0.08331227,0.1656722,0.0002911504,0.002111284,0.00006663059,0.007081067,0.0009617244,0.0003742246,0.00006234313,0.0008039288,0.0003484277],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986889,0.0006315056,0.0005652271,0.007209129,0.0003329028,0.002415845,0.001933099,0.00001239846,0.00001086942],"genre_scores_gemma":[0.997342,0.0001159807,0.0007027204,0.001091558,0.0003334731,0.0001119294,0.0002588715,0.00003876337,0.000004741911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5629691,"threshold_uncertainty_score":0.9999775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0159145577478778,"score_gpt":0.3396527997802569,"score_spread":0.3237382420323791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}