{"id":"W3094100911","doi":"10.1016/j.ijrobp.2020.07.953","title":"NRG Oncology/RTOG 1119: PHASE II Randomized Study of Whole Brain Radiotherapy/Stereotactic Radiosurgery with Concurrent Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer — A Collaborative Study of NRG and KROG (NCT01622868)","year":2020,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Lapatinib; Radiosurgery; Breast cancer; Radiation therapy; Oncology; Clinical endpoint; Internal medicine; Pertuzumab; Brain metastasis; Metastatic breast cancer; Cancer; Randomized controlled trial; Trastuzumab; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002148177,0.002208083,0.002609589,0.0005671267,0.0005435567,0.001218724,0.001495497,0.001397255,0.008861236],"category_scores_gemma":[0.001481446,0.000987131,0.001993962,0.000703396,0.001304586,0.001079718,0.0005905697,0.004244081,0.001740464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00163233,"about_ca_system_score_gemma":0.002441994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003935009,"about_ca_topic_score_gemma":0.01262994,"domain_scores_codex":[0.999281,0.0004059333,0.00003166645,0.0001348378,0.00004714982,0.00009944532],"domain_scores_gemma":[0.9991192,0.0001491488,0.0002207777,0.00007489995,0.00003545059,0.0004004713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9381506,0.01854063,0.001828322,0.0006330714,0.001662562,0.00005060378,0.000110544,0.001178043,0.005373842,0.0002637917,0.003741724,0.02846619],"study_design_scores_gemma":[0.9393926,0.05532887,0.002608275,0.00002021351,0.0004952815,0.00005011259,0.000036146,0.0004649073,0.0003408519,0.0001576871,0.001085842,0.00001910298],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808326,0.002754062,0.001098344,0.001134423,0.0005312582,0.005384165,0.003712524,0.0002741646,0.004278471],"genre_scores_gemma":[0.9689673,0.003593222,0.003893122,0.00235654,0.0004541306,0.006471919,0.005818457,0.0001496935,0.008295507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008861236,"threshold_uncertainty_score":0.02964383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0159145577478778,"score_gpt":0.3396527997802569,"score_spread":0.3237382420323791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}