{"id":"W3094163937","doi":"10.1534/g3.120.401876","title":"Chemical-Genetic Interactions with the Proline Analog L-Azetidine-2-Carboxylic Acid in <i>Saccharomyces cerevisiae</i>","year":2020,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Western University","funders":"","keywords":"Saccharomyces cerevisiae; Genetic screen; Amino acid; Biochemistry; Genetic code; Biology; Chemistry; Gene; Yeast; Cell biology; Genetics; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383208,0.0004225014,0.0002978542,0.0002423516,0.0001527194,0.0003828068,0.000280432,0.000232824,0.0006630474],"category_scores_gemma":[0.000146262,0.0001410382,0.0002634198,0.0002348943,0.0001793701,0.0001035398,0.0002134563,0.0003482605,0.0002445049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004777363,"about_ca_system_score_gemma":0.0002440426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002646743,"about_ca_topic_score_gemma":0.002848563,"domain_scores_codex":[0.999772,0.00004293875,0.00003001711,0.00004184484,0.00008361703,0.00002952342],"domain_scores_gemma":[0.999804,0.00004626192,0.00006289947,0.00002178945,0.00002516321,0.0000399136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004768814,0.00001467525,0.0002305835,0.00001489939,0.000004953344,0.00004515164,0.000004645609,0.00006572439,0.999118,0.00002667516,0.00001502006,0.0004119905],"study_design_scores_gemma":[0.00000464955,0.0001338487,0.003278121,0.000002725027,0.00001455768,0.0001586977,0.00001943358,0.0006328495,0.994907,0.00001170492,0.0008322173,0.000004258098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961678,0.0005413422,0.001598489,0.00006065825,0.00001945559,0.00002286887,0.0005855023,0.00007656772,0.0009272428],"genre_scores_gemma":[0.9945346,0.0003500394,0.002444981,0.00004872203,0.000005158339,0.00002318714,0.0009219865,0.00004857881,0.001622723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002646743,"threshold_uncertainty_score":0.005262673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01424325100759314,"score_gpt":0.2265143908042034,"score_spread":0.2122711397966102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}