{"id":"W3094193352","doi":"10.1002/cncr.33188","title":"Phase 1 study to evaluate Crenigacestat (LY3039478) in combination with dexamethasone in patients with T‐cell acute lymphoblastic leukemia and lymphoma","year":2020,"lang":"en","type":"article","venue":"Cancer","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"National Institutes of Health; Eli Lilly and Company","keywords":"Medicine; Nausea; Dexamethasone; Vomiting; Gastroenterology; Internal medicine; Diarrhea; Lymphoblastic lymphoma; Cohort; Adverse effect; T cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009796899,0.001267595,0.001867701,0.0004772391,0.0003722203,0.0007089846,0.0009723067,0.0009446474,0.003666148],"category_scores_gemma":[0.0006252337,0.0004778671,0.0007924715,0.0004621012,0.0006461584,0.0005224909,0.0003325577,0.00224968,0.0009784824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001126778,"about_ca_system_score_gemma":0.002135011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552987,"about_ca_topic_score_gemma":0.003663954,"domain_scores_codex":[0.9996607,0.0001758167,0.00001506604,0.00005429951,0.00003190625,0.00006219821],"domain_scores_gemma":[0.9994821,0.0000671174,0.00009920727,0.00003963792,0.00003465857,0.0002772373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6742903,0.09204788,0.01332987,0.001136507,0.001641264,0.0007718281,0.000375405,0.004156892,0.08147041,0.0004675407,0.005591272,0.1247209],"study_design_scores_gemma":[0.5768809,0.4039594,0.009112025,0.00003919746,0.0003799993,0.0005028343,0.00006061153,0.000874872,0.004232259,0.0001480744,0.003790042,0.00001983103],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901045,0.002553615,0.0005501201,0.0004935201,0.00009991725,0.003576027,0.001069814,0.0001002513,0.00145212],"genre_scores_gemma":[0.9884866,0.001840853,0.001803725,0.0007817443,0.0001286544,0.003452976,0.001762567,0.00002954295,0.001713173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003666148,"threshold_uncertainty_score":0.01226455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0188443904820772,"score_gpt":0.3102680158659736,"score_spread":0.2914236253838964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}